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Full-Text Articles in Physical Sciences and Mathematics
Proposed Mechanism Of Alzheimer’S Disease: The Role Of Oxidative Stress A Review Of Scientific Literature, Alicia Monahan
Proposed Mechanism Of Alzheimer’S Disease: The Role Of Oxidative Stress A Review Of Scientific Literature, Alicia Monahan
Senior Honors Projects
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that has become the sixth leading cause of death in the United States. The most notable neuropathological hallmarks of AD are the accelerated accumulation of β-amyloid deposits around neurons and the accumulation of neurofibrillary tangles (NFT) within neurons. These abnormalities block proteasome function, inhibit mitochondrial function, alter biometal levels, stimulate inflammatory processes, disrupt synaptic communication, and ultimately result in cell death. Mitochondrial dysfunction has been cited as an underlying cause of AD pathologies, specifically by enhancing the production and accumulation of β-amyloid. Once the β-amyloid oligomers form, they disrupt the Ca2+ …
Effects Of Oxidative Stress On J774 Macrophages, Katelyn Chessier
Effects Of Oxidative Stress On J774 Macrophages, Katelyn Chessier
Senior Honors Projects
No abstract provided.