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Full-Text Articles in Physical Sciences and Mathematics
Advances In Raman Hyperspectral Compressive Detection Instrumentation For Fast Label Free Classification, Quantitation And Imaging, Bharat R. Makani
Advances In Raman Hyperspectral Compressive Detection Instrumentation For Fast Label Free Classification, Quantitation And Imaging, Bharat R. Makani
Open Access Dissertations
Multiple prototypes of hyperspectral compressive detection (CD) Raman spectrometers have previously been constructed in the Ben-Amotz lab and have proven to be useful for fast, label-free chemical identification, quantitation and imaging. The CD spectrometer consists of a volume holographic grating (VHG) that linearly disperses the Raman photons into its component wavelengths and all wavelengths are focused onto a digital micromirror devise (DMD). The DMD is an optical modulator that consists of an array of programmable 10μm mirrors that can reflect photons in either +12° or -12° to the incoming light. The DMD is tilted such that the +12° photons go …
Multivariate Statistical Methods That Enable Fast Raman Spectroscopy, Owen G. Rehrauer
Multivariate Statistical Methods That Enable Fast Raman Spectroscopy, Owen G. Rehrauer
Open Access Dissertations
Raman spectroscopy is a useful tool in investigating inter- and intra-molecular interactions as well as classifying and quantifying chemical species in a sample. Many materials of societal interest, such as proteins and pharmaceuticals, have distinctive Raman spectra with sharp features. However, the adoption of Raman spectra has been hindered by the low rate of Raman scattering, interference from fluorescence, and high spectrometer costs. This work demonstrates multivariate stastical methods that enable fast Raman measurements, despite the low rate of Raman scattering. These methods include a novel type of spectrometer, that uses computer-controlled optical filters to efficiently capture Raman photons and …