Physical Sciences and Mathematics Commons^™

Glass Foundation Chemosensor Synthesis And Functionality Analysis, Justin D. Dancer

Master's Theses

Chemosensors are created through a series of reaction steps on controlled pore class (CPG) and terminate with a Cu²⁺ metal binding site. Each monolayer of reactant insures that the metal binding site exposed to solution would serve as an indicator displacement assay (IDA) sensor. The purpose of this research is to create a molecular sensor with a high density of terminal metal sites to quantify bidentate substrates. To accomplish this, each synthetic step of the sensor is examined in order to test the effects of new linkers, ligands, and variously sized dendrimers to see if small structural changes could …

Surface Tethered Pamam Dendrimers On Controlled Pore Glass As Color Release Sensors For Phosphates, Chang Liu

Master's Theses

Poly(amidoamine) dendrimer (PAMAM) are highly branched macromolecules with reactive amine groups in their interior and exterior. PAMAM dendrimers were attached to controlled pore glass (CPG) surfaces in order to create new functionalized surfaces and used as platforms for UV-vis and fluorescent sensing of phosphate substrates via indicator displacement assays (IDA).

CPG surfaces were first modified with different sized PAMAM dendrimers (generation 3.0, 4.0, and 5.0), then reacted with two strong metal-chelators: aminofunctionalized terpyridine (synthesized from 2,2’:6’,2’’-terpyridine) and Nα-Nα-bis(carboxymethyl)-L-lysine (Lys-NTA). First of all, Cu(II) metal ion binding capacities were measured on the surfaces. Second, two terminal group density tests, amine assay …