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Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of Fluorescent Poly(Styrene Sulfonate), Wayne Alfred Huberty
Synthesis Of Fluorescent Poly(Styrene Sulfonate), Wayne Alfred Huberty
LSU Master's Theses
In 1978, Lee found an increase and then a large decrease in the diffusion coefficient of poly(lysine) as the concentration of salt is decreased (Lin, S. C.; Lee, W. I.; Schurr, J. M. Biopolymers 1978, 17, (4), 1041-1064). Since the “slow mode” discovery, many have studied it without finding a fully satisfactory answer. Additional dynamic light scattering (DLS) measurements have been the main experimental technique used for reinvestigating the slow mode decay. Although DLS is a powerful characterization tool, it depends on thermodynamic interactions. As complicated as they can be, thermodynamic interactions are much worse for polyelectrolytes because of the …
Kinetic Studies On Lactonization Of Quinone Propionic Acid Derivatives For The Development Of Redox Responsive Liposomes, K. L. Iresha Sampathi Perera
Kinetic Studies On Lactonization Of Quinone Propionic Acid Derivatives For The Development Of Redox Responsive Liposomes, K. L. Iresha Sampathi Perera
LSU Master's Theses
ABSTRACT Stimuli-responsive liposome systems that utilize endogenous triggers of tumor microenvironment have generated great attention in recent drug delivery research. Among such formulations, redox-responsive liposomes seem highly promising for cancer treatment due to their potential to release high drug concentrations upon reduction (by reductase enzymes). The research described in this thesis involved the evaluation of kinetics of trimethyl-lock quinone propionic acid reduction and lactonization, which accounts for payload release from trimethyl-lock quinone propionic acid-decorated liposomes. To achieve the ultimate goal of this research, several trimethyl-lock quinone propionic acid-based amide compounds were synthesized and characterized. Kinetic studies were carried out with …