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Full-Text Articles in Physical Sciences and Mathematics
Turn-On Near-Infrared Fluorescent Sensors For Selective Monitoring Of Kinase Activity, Gerard Thomas Ducharme
Turn-On Near-Infrared Fluorescent Sensors For Selective Monitoring Of Kinase Activity, Gerard Thomas Ducharme
LSU Doctoral Dissertations
Reliable and selective detection of specific biopolymers is critical in a broad range of biomedical and technological areas, including availability of simple and efficient point-of-care-compatible systems for the detection of prognostic, pharmacodynamic and predictive biomarkers. Monitoring epidermal growth factor receptor (EGFR) tyrosine kinase is of major significance due to its link to many epithelial cancers. This task is complicated by the high rate of mutation occurring in patients treated with kinase inhibitors. This dissertation describes a conceptually novel design and synthesis of turn-on near-infrared fluorescent sensors for selective and sensitive detection of EGFR. The fluorescent signal generation mechanism is based …
Design, Synthesis, And Evaluation Of Innovative Bodipy-Peptidic Conjugates For Biological Application, Tyrslai Menyaee Williams
Design, Synthesis, And Evaluation Of Innovative Bodipy-Peptidic Conjugates For Biological Application, Tyrslai Menyaee Williams
LSU Doctoral Dissertations
Abstract Chapter 1 provides a brief introduction to colorectal cancer (CRC), methods of detection, photodynamic therapy (PDT), and EGFR as an attractive targeting strategy for imaging CRC. Chapter 2 details the synthesis of ten peptide sequences for targeting EGFR receptors at the site of CRC, as a collaborative work with Dr. Seetharama Jois. This chapter also investigates the efficacy of these peptides for EGFR. Chapter 3 offers the first synthetic strategy for developing BODIPY-peptide conjugates via amide linkages. All conjugates were optimized for the best reaction conditions and good yields were observed. Each conjugate was subjected to photophysical, SPR, and …