Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Alpha-Synuclein (1)
- Amidation (1)
- Biomarkers (1)
- Bromination (1)
- Cancer (1)
-
- Cortisol (1)
- Electrochemistry (1)
- Glucose (1)
- Hantzsch thiazol condensation (1)
- Hydrogen peroxide (1)
- INH1 analog CAS# 560103-80-2 (1)
- Nec2/Nek1 inhibitor (1)
- Neuroblastoma (1)
- Oncogenes (1)
- Parkinson's Disease (1)
- Pollution (1)
- Prussian blue (1)
- Saliva (1)
- Sample Handling (1)
- Stability (1)
- Storage (1)
- Xerogel (1)
Articles 1 - 10 of 10
Full-Text Articles in Physical Sciences and Mathematics
The Effect Of Different Vegetable Oils (Macadamia Nut Oil And Walnut Oil) On The Coefficient Of Friction As A Finish For Oak Wood, Lee Dillon
Journal of the South Carolina Academy of Science
Slipping due to insufficient friction with flooring can cause fatal injuries in workplaces and homes. Oak wood flooring is commonly used in construction to build these environments. In the manufacturing process, wood finishing is conducted at the end of the process to strengthen the properties and longevity of the wood, although it could impact the coefficient of friction (COF) causing slip falls. Vegetable oils, such as macadamia nut and walnut oils, used as wood finishes have gained prominence due to their beneficial aspects to the environment. However, little is known about their effectiveness as a safe coating for wood floors. …
Cortisol And Alpha-Synuclein Stability In Saliva Under Varying Storage And Handling Conditions, Mo Zheng, Sujata Srikanth, Jeremiah Carpenter, Delphine Dean
Cortisol And Alpha-Synuclein Stability In Saliva Under Varying Storage And Handling Conditions, Mo Zheng, Sujata Srikanth, Jeremiah Carpenter, Delphine Dean
Journal of the South Carolina Academy of Science
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments and non-motor symptoms, significantly impacting patients' quality of life. Currently, cerebrospinal fluid (CSF) is the primary biofluid used for PD biomarker studies, notably α-synuclein, despite the invasive nature of lumbar puncture procedures. Recent work has shown that some of these PD biomarkers have been measured in saliva. As an alternative to CSF, saliva can be non-invasively self-collected by patients repeatedly over time to monitor biomarker levels. However, the stability of these biomarkers in saliva needs to be evaluated before saliva can be considered for patient self-collection studies. Therefore, …
Table Of Contents
Journal of the South Carolina Academy of Science
No abstract provided.
Examination Of Oncogenic Effects Of Environmental Pollutants, Andrew Ackerman, Matthew Behling, Brock Earley, Janay Vacharasin
Examination Of Oncogenic Effects Of Environmental Pollutants, Andrew Ackerman, Matthew Behling, Brock Earley, Janay Vacharasin
Journal of the South Carolina Academy of Science
Chemical byproducts produced by surrounding industrial complexes have polluted the local estuaries of Georgetown, South Carolina for several decades1. Previous studies completed by the EPA and SCDNR showed that the estuaries contained carcinogenic pollutants released from the local manufacturing plants1. One of the mentioned pollutants was dioxins which are produced during the paper bleaching process2. Dioxins are highly toxic compounds that have various carcinogenic effects on the organisms that inhabit the area. These previous studies were conducted over thirty years ago. Therefore, a current study to determine if chemical byproducts are contaminating local estuaries …
Striatal Beat Frequency Interval Timing Model With Microgravity Stressor, Jason Michael Fitzgerald, Sorinel Oprisan
Striatal Beat Frequency Interval Timing Model With Microgravity Stressor, Jason Michael Fitzgerald, Sorinel Oprisan
Journal of the South Carolina Academy of Science
The Striatal Beat Frequency (SBF) model of interval timing uses frontal cortex (FC) neural oscillations to record the state of the brain at the reinforcement time Tc during fixed interval (FI) procedures in the long-term memory (LMEM). The state of the FC oscillators at any given time is stored in a short-term memory (SMEM) buffer. The SBF model uses the spiny neurons of the basal ganglia (BG) as coincidence detectors to produce beats between the content of the SMEM and LMEM. Across multiple species that can perform interval timing, there are two invariant properties: (a) the timing is precise, and …
Potential Nec2/Nek1 Inhibitor And Inh1 Analog N-[4-(2,4-Dimethylphenyl)-2-Thiazolyl]-4-Pyridinecarboxamide Via Hantzsch Thiazol Condensation, Robert E. Lee Sr, Isabella G. Mcdonald, Paige E. Heiple, Lukas D. Shelton
Potential Nec2/Nek1 Inhibitor And Inh1 Analog N-[4-(2,4-Dimethylphenyl)-2-Thiazolyl]-4-Pyridinecarboxamide Via Hantzsch Thiazol Condensation, Robert E. Lee Sr, Isabella G. Mcdonald, Paige E. Heiple, Lukas D. Shelton
Journal of the South Carolina Academy of Science
The potential active pharmaceutical ingredient (API), N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide (6) is a cancer cell metabolism mitosis inhibitor via the Nek2 and Hec1 enzymes. The three-step synthesis starts with the bromination of 1-(2,4-dimethylphenyl)ethan-1-one (1) using CuBr2 to produce 2-bromo-1-(2,4-dimethylphenyl)ethan-1-one (2) with a yield of 90%.[i],[ii],[iii] Followed by Hantzsch thiazol ring synthesis as (2) reacts with thiourea (3) and, resulting in 4-(2,4-dimethylphenyl)thiazol-2-amine (4)[iv] in 80% yield. Finally, isonicotinoyl chloride hydrochloride (5) and (4) reacted to form the amide (6).[v],[vi],[vii],[viii],[ix],[x] Characterization of the final product was determined …
Electrochemical Detection Of Glucose Using A Prussian Blue Modified Electrodes Combined With Glucose Encapsulated Within A Xerogel, Daniel Baker, Sarah Davis, Drew Budner
Electrochemical Detection Of Glucose Using A Prussian Blue Modified Electrodes Combined With Glucose Encapsulated Within A Xerogel, Daniel Baker, Sarah Davis, Drew Budner
Journal of the South Carolina Academy of Science
Recent literature reports examples of electrochemical biosensor systems that have been developed based upon on the encapsulation of enzymes and metal nanoparticles into a xerogel. These systems have been utilized for the detection of biologically important compounds, such as glucose. These reports on these systems have found acceptable detection limits and linear ranges. At the same time, Prussian blue modified electrodes have been shown to have better operating parameters than metal electrodes for the detection of hydrogen peroxide. In this work, a biosensor system is described that incorporates the encapsulation of glucose oxidize within a xerogel combined with electrochemical detection …
Technology Development And Materials Research To Enable A Sustainable D-T Fusion Energy Fuel Cycle, Brenda L. Garcia-Diaz, David Babineau, James Klein, Robert Allgood, George Larsen, Holly B. Flynn, Dale Hitchcock, Tim Krentz, Chris Dandeneau, Lucas Angelette, Robert Sindelar
Technology Development And Materials Research To Enable A Sustainable D-T Fusion Energy Fuel Cycle, Brenda L. Garcia-Diaz, David Babineau, James Klein, Robert Allgood, George Larsen, Holly B. Flynn, Dale Hitchcock, Tim Krentz, Chris Dandeneau, Lucas Angelette, Robert Sindelar
Journal of the South Carolina Academy of Science
No abstract provided.
Table Of Contents
Journal of the South Carolina Academy of Science
No abstract provided.
Table Of Contents
Journal of the South Carolina Academy of Science
No abstract provided.