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Full-Text Articles in Physical Sciences and Mathematics
Identification, Synthesis And Biological Activity Of Galloyl Inhibitors Of Human Low Molecular Weight Protein Tyrosine Phosphatase, Samuel T. Klinker
Identification, Synthesis And Biological Activity Of Galloyl Inhibitors Of Human Low Molecular Weight Protein Tyrosine Phosphatase, Samuel T. Klinker
Honors Theses, 1963-2015
Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) isoform 2 (IF2) has been found to be over expressed in many forms of aggressive cancer and has become a target for inhibition. Competitive inhibition of LMW-PTP IF2 by known inhibitor pyridoxal-5'-phosphate (PLP) shows a strong inhibition constant (Ki = 7.6 μM at pH 5.0); however, PLP is a cofactor for many other enzymes. In silico screening and in vitro testing identified NSC107022 (Ki = 10.8 ±1.0) from the National Cancer Institute's Diversity Set II as a lead compound for optimization as a LMW-PTP IF2 inhibitor. Utilizing NSC107022's galloyl group, compound libraries of …
Polyurethane Research For Applications In The Field Of Dentistry: Limiting Side Reactions In Monomer Development And Synthesizing N-Capped Polymenthide, Ellen M. (Ellie) Black
Polyurethane Research For Applications In The Field Of Dentistry: Limiting Side Reactions In Monomer Development And Synthesizing N-Capped Polymenthide, Ellen M. (Ellie) Black
Honors Theses, 1963-2015
Modern dentistry has found uses for polyurethanes in both dental arch models and removable dental appliances. In an attempt to make polyurethanes from renewable resources, both naturally derived menthone and dihydrocarvone were oxidized in order to form menthide and dihydrocarvide, respectively. The resulting ester, if copolymerized could be modified to form a polyuria; however, dihydrocarvide synthesis was complicated by epoxidation. Different reaction environments with varying salts showed no positive effect on limiting epoxide products. A homopolymerization of menthide resulted in a polymenthide chain that was reacted in the presence of N,N'-Dicyclohexylcarbodiimide (DCC) in order to form an N-capped polymenthide chain. …
Investigations Into Uncharacterized Radical S-Adenosylmethionine Enzymes, Melissa Quintanilla
Investigations Into Uncharacterized Radical S-Adenosylmethionine Enzymes, Melissa Quintanilla
Honors Theses, 1963-2015
Radical S-adenosylmethionine (SAM) enzymes are a superfamily of enzymes that require the cofactor SAM for catalysis. These enzymes have diverse functions across all 3 domains of life, and are known to play roles in many biological pathways, including vitamin biosynthesis, synthesis of complex metal clusters, posttranslational RNA modification,DNA repair, and development of antibiotic resistance, among others. Radical SAM enzymes are characterized by the CX3CX2C motif, which is conserved throughout most members of the family. A number of genes have been identified which contain the CX3CX2C motif and other amino acid sequences …
The Synthesis Of Dendrimer-Bound Catalysts And Their Use In Macmillan-Type Reactions, Autumn R. Flynn
The Synthesis Of Dendrimer-Bound Catalysts And Their Use In Macmillan-Type Reactions, Autumn R. Flynn
Honors Theses, 1963-2015
Dendrimers—highly branched macromolecules—present an attractive option for use as a catalytic framework because of their large size and their availability for functionalization. In addition, the use of organocatalysts to form asymmetric products has become an increasingly studied field in the pharmaceutical industry and cancer research. Organocatalyst terminally functionalized dendrimers present the possibility of both catalytic utility and increased recovery in MacMillan-type asymmetric reactions. Terminal sites of generations 2.0, 3.0, and 4.0 PAMAM dendrimers have been functionalized with the MacMillan group's (2S, 5S)-5-benzyl-2-tert-butyl-3-methylimidazolidin-4-one catalyst. These functionalized PAMAM dendrimers were characterized by NMR and MALDITOF MS analysis. The organocatalyst functionalized dendrimers show …
Determination Of Inhibitor Specificity For Low Molecular Weight Protein Tyrosine Phosphatase Isoforms A And B, Erica K. Sinner
Determination Of Inhibitor Specificity For Low Molecular Weight Protein Tyrosine Phosphatase Isoforms A And B, Erica K. Sinner
Honors Theses, 1963-2015
The two active isoforms of Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) have inverse cellular effects on cancer. Isoform A has been found to be anti-oncogenic, while overexpression of Isoform B is oncogenic. Inhibitors of Isoform B could have anti-cancer effects, however, it is of utmost importance that these inhibitors exhibit specificity for Isoform B and do not affect the function of Isoform A. Isoform A was recombinantly expressed, purified and characterized in order to compare its structure and function to Isoform B. It is hoped that this characterization, along with the synthesis and screening of potential inhibitors for both …