Physical Sciences and Mathematics Commons^™

Synthesis And Characterization Of A Biometric Model Of The Tricopper Binding Site Of Multicopper Oxidases, Haosen Wang

Honors Theses, 1963-2015

This research employs the principles of bioinorganic modeling, simplifying the extraneous structures of the molecule being mimicked and focusing only on the active components of the large biological molecules. Specifically, this project attempts to mimic the structure and reactivity of tri-copper active sites found in Multi-copper Oxidises, such as Laccase and Ceruloplasmin, that bind with oxygen and reduce it to water. After experimenting with various other structures that failed to mimic the active sites, we selected another potential ligand, 1,3,5-tri(2-pyridylmethyltriazole)-2,4,6-triethyl benzene, abbreviated L_tapma, to be the substrate for this research to bind with three Cu(I) ions and then …