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Full-Text Articles in Physical Sciences and Mathematics
Synthesis And Characterization Of A Trypsin Inhibitor, Eric L. Schneider
Synthesis And Characterization Of A Trypsin Inhibitor, Eric L. Schneider
Honors Theses, 1963-2015
Inhibitors of biological enzymes are frequently produced by mimicking the molecular structure of the enzyme's natural substrate. Because of the extensive studies that have already been performed on the trypsin enzyme, its natural substrates and its mode of interaction with them are well understood. By finding an easily synthesized molecule to inhibit the trypsin enzyme, college level laboratory experiments could be designed and integrated into organic chemistry and biochemistry courses. In this project, a possible trypsin inhibitor molecule, 4-fluorobenzylaimine, was chosen based on its similarity to the natural trypsin substrates and because it has been predicted through computational studies to …
The Synthesis And Characterization Of Monometallic And Bimetallic Pd-Pnp Complexes, Lorinda Asmus
The Synthesis And Characterization Of Monometallic And Bimetallic Pd-Pnp Complexes, Lorinda Asmus
Honors Theses, 1963-2015
The bridging ligand, 2-[bis(diphenylphosphino)methyl]pyridine (PNP), is ideal for synthesizing mono- and bi-metallic catalysts due to its potential to be bidentate (P-P or P-N) or tridentate and its ability to bind to one or more metals. Three Pd-PNP complexes, [Pd(PNP)2]+2 (1) and two complexes resulting from the removal of one or two methine pronouns (2 and 3), have been synthesized. The removal of one methine proton changes the PNP bidentate binding mode. In complex 1 and 3, the two PNP ligands are P-P bound. However, upon the removal of one methine proton, one …