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Full-Text Articles in Physical Sciences and Mathematics
Dinetic And Mechanistic Investigations Of Photocatalysis : Photoreactions Of Cr(Co)6 With Alkenes, Aaron E. Dietrich
Dinetic And Mechanistic Investigations Of Photocatalysis : Photoreactions Of Cr(Co)6 With Alkenes, Aaron E. Dietrich
Honors Theses
Flash photolysis has proven to be an effective technique for determining reaction mechanisms. Upon photolysis, a CO ligand is removed from Cr(CO)6 forming the reactive molecular fragment Cr(C0)5. In the presence of alkene, L, Cr(CO)s can react to form the meta-stable intermediate Cr(C0)5L. At high L concentrations, Cr(CO)5L decays by pseudo-first-order kinetics with an observed rate constant, kobs, which is dependent on the concentration of both L and added CO. The exar.t nature of the dependence provides insight into the mechanism of the decay of Cr(C0)5L and a plot of 1/kobs vs. [L] will give the rate constants for both …
Studies Directed Toward The Enantioselective Addition Of Reformatsky Reagents To Aldimines, Lamyaa Hassib
Studies Directed Toward The Enantioselective Addition Of Reformatsky Reagents To Aldimines, Lamyaa Hassib
Honors Theses
Interest in β-amino esters and β-lactams has grown significantly due to their applications in the synthesis of compounds of pharmaceutical interest. Examples include β-lactam antibiotics such as the penicillin and carbapenem families. Because β-lactams and β-amino esters share a common pathway, methods to prepare either are often contaminated and thus complicated by the formation of the other. We have developed convenient and highly controllable method which can afford either product cleanly.
Studies Directed Toward The Enantioselective Addition Of Reformatsky Reagents To Aldimines, Lamyaa Hassib
Studies Directed Toward The Enantioselective Addition Of Reformatsky Reagents To Aldimines, Lamyaa Hassib
Honors Theses
Interest in β-amino esters and β-lactams has grown significantly due to their applications in the synthesis of compounds of pharmaceutical interest. Examples include β-lactam antibiotics such as the penicillin and carbapenem families. Because β-lactams and β-amino esters share a common pathway, methods to prepare either are often contaminated and thus complicated by the formation of the other. We have developed convenient and highly controllable method which can afford either product cleanly.
Molecular Design And Association Constants Of Nizatidine-Guest Complexes, Elizabeth Corbeil
Molecular Design And Association Constants Of Nizatidine-Guest Complexes, Elizabeth Corbeil
Honors Theses
Nizatidine, N-[2-[[[2-[(dimethylamino)metbyl]-4-thiazolyl]methyl]thio]ethyl]-N'methyl- 2-nitro-l,l-ethenediamine (Axid"), has been investigated for its potential to act as a host in guest-host complexes. Nizatidine binds with the guests through hydrogen bonding and pi-pi interactions. Guest-host studies were conducted using fluorescence quenching, calorimetry, NMR and invisible experiments. The lowest energy conformation of nizatidine is found to be U-shaped through theoretical calculations. Fluorescence experiments indicated that tryptophan and pyridoxine had large association constants. Further studies using calorimetry and NMR techniques concluded that no complexation had occurred. Complexation experiments have been done to find guests that complex with nizatidine. Caffeine, luminol, nicotinamide, phenylalanine, pyridoxine, pyrogallol, and tryptophan were …
A Method For The Determination Of Purity Of Pnu-10483 Bulk Drug By Capillary Zone Electrophoresis, Gavin Gibson
A Method For The Determination Of Purity Of Pnu-10483 Bulk Drug By Capillary Zone Electrophoresis, Gavin Gibson
Honors Theses
In this investigation, a method was developed for the determination of purity of the drug PNU-10483 using the technique of capillary zone electrophoresis (CZE). CZE was seen as a potential alternative to the formerly used procedure of ion-pair reversed phase highperformance liquid chromatography (HPLC). Nearly five years earlier, a similar study was performed, in which an attempt was made to develop a method that used CZE to determine the purity of bulk drug and the potency of drug tablets. While this development was mostly successful, sporadically unpredictable results reduced the method's overall viability. These outliers were thought to be caused …
Approaches And Methodologies For The Synthesis Of Aromatic Natural Products, Christina A. Goudreau
Approaches And Methodologies For The Synthesis Of Aromatic Natural Products, Christina A. Goudreau
Honors Theses
Chemists have been captivated by the ability of most natural products to exhibit biological activity which in effect has made them very attractive to pharmaceutical companies. Many over-the-counter drugs such as aspirin were first extracted from natural products and are now an integral part of most of our lives. More importantly, certain drugs such as taxol, which is used to treat breast cancer, initially came from the bark of a yew tree. Extracting these substances from their natural source and using them medicinally at the demand of the consumers would result in the destruction of the natural habitat. Oftentimes, the …
Alternatives To Nitroprusside, William T. Hiscock
Alternatives To Nitroprusside, William T. Hiscock
Honors Theses
Any transition metal nitrosyl complex may release nitric oxide and thus has potential as a vasodilator. Nitroprusside, Na2[Fe(CN)5(NO)], is currently used, but dosages are limited because of the potential release of cyanide. Research in our group has been directed towards the synthesis of iron and ruthenium complexes containing the nitrosyl ligand and polypyridyl coligands such as 2,2-dipyridyl (bpy) and 2,2': 6',2"-terpyridine (tpy). These coligands are much less toxic than cyanide. Both [(bpy)(tpy)Fe(NO)]3+ and [(bpy)(tpy)Ru(NO)]3+ have been synthesized and characterized using infrared and ultraviolet spectroscopy, conductivity, and magnetic susceptibility. Along with the search for other possible polydentate coligands, is the search …