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Full-Text Articles in Physical Sciences and Mathematics
Pursuit Of A Chiral Amino Aldehyde Intermediate In The Synthesis Of (+)-Obafluorin, A B-Lactone Antibiotic, Jim Cwik '96
Pursuit Of A Chiral Amino Aldehyde Intermediate In The Synthesis Of (+)-Obafluorin, A B-Lactone Antibiotic, Jim Cwik '96
Honors Projects
This research is focused on synthesizing a chiral amino aldehyde from L-Serine. The proposed synthesis of the amino aldehyde would yield a stereochemically pure product working through an L-Serine beta-lactone intermediate. The amino aldehyde is a proposed intermediate in the synthesis of (+)-obafluorin, a beta-lactone antibiotic of interest. The proposed synthesis might provide a simpler, more versatile way to synthesize obafluorin.
Toward An Efficient Method Of Detecting Cocaine Metabolite In Urine, C.J. Summers '96
Toward An Efficient Method Of Detecting Cocaine Metabolite In Urine, C.J. Summers '96
Honors Projects
The primary metabolite of cocaine is benzoyl ecognine (BE). A desirable method for detecting cocaine use is the extraction of BE from urine into an organic phase solvent and subsequent analysis by High Performance Liquid Chromatography (HPLC). The attempt to develop such a method is hindered by the extreme water solubility of BE, making extraction into an organic phase extremely difficult. The present study attempts to use an ion-pairing agent to bind with BE and form a large, organically soluble ion-pair. The ion pairing agent used was Reinecke Salt in a I% solution. An aqueous solution of 50 ug/mL BE …
The Synthesis Of An Organophosphorus Analog Of Acetylcholine, Jay-James R. Miller '96
The Synthesis Of An Organophosphorus Analog Of Acetylcholine, Jay-James R. Miller '96
Honors Projects
Acetylcholine (ACh) is the most widely studied of all neurotransmitter substances. For normal nerve function, the enzyme acetylcholinesterase (AChE) must hydrolyze ACh into its basic chemical constituents, choline and acetate. AChE is readily inhibited by organophosphorus (OP) compounds like sarin and soman--both nerve gases--as well as various pesticides. OP compounds also have been widely used to study the mechanism of ACh hydrolysis via AChE. In the 1980s, two studies using OP inhibitors examined the stereoselectivity of AChE hydrolysis. However, they yielded conflicting results. Hence, it is hoped that new studies with a novel OP compound will provide definitive information about …