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Full-Text Articles in Physical Sciences and Mathematics
Synthesis And Functionality Study Of Novel Biomimetic N-Glycan Polymers, Ka Keung Chan
Synthesis And Functionality Study Of Novel Biomimetic N-Glycan Polymers, Ka Keung Chan
ETD Archive
Cell surface carbohydrates, existing as glycoproteins, glycolipids, and proteoglycans, often serve as receptors to relay critical interactions and trigger crucial signaling events in many biological processes. Glycan recognition is deeply involved in immune surveillance, response and can provide abundant opportunities to discover the molecular mechanism and potential therapeutic or diagnostic approaches for various diseases. Many useful functionalities can be achieved by developing synthetic glycans to mimic natural carbohydrates. Over the recent decade, glycopolymers, polymers with pendant carbohydrates, have continued to prove usefulness in various applications across different scientific disciplines. For example, glycopolymers can be used as biomimetic glycoligands to study …
Synthesis, Characterization, And Catalytic And Biological Activities Of A Mixed-Ligand Cobalt(Ii) Bipyridyl/Diphenylazodioxide Complex, Kylin A. Emhoff
Synthesis, Characterization, And Catalytic And Biological Activities Of A Mixed-Ligand Cobalt(Ii) Bipyridyl/Diphenylazodioxide Complex, Kylin A. Emhoff
ETD Archive
Transition metal complexes have immense importance in the pharmaceutical industry. These types of complexes can be useful catalysts in the synthesis of medicinal compounds and can act as anticancer drugs. In these pharmaceutical applications, 1st-row transition metal-containing complexes offer certain advantages compared to their 2nd and 3rd-row transition metal counterparts. Our motivation was to investigate pharmaceutical applications of transition metal complexes containing both a 1st-row transition metal and unusual ligands to expand the knowledge of a class of complexes that could potentially be beneficial in the pharmaceutical industry. A class of rare ligands that piqued our interest was that of …