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Full-Text Articles in Physical Sciences and Mathematics
The Role Of Platelets In Hyaluronan Degradation, Sami Albeiroti
The Role Of Platelets In Hyaluronan Degradation, Sami Albeiroti
ETD Archive
Following tissue injury, platelets rapidly interact with the exposed extracellular matrix (ECM) of blood vessel wall and the surrounding tissues. Hyaluronan (HA) is a major polysaccharide component of the ECM and plays a significant role in regulating inflammation. Human platelets can degrade HA from the surfaces of activated endothelial cells into fragments capable of inducing immune responses by monocytes. In addition, platelets contain the enzyme hyaluronidse-2 (HYAL2), one of two major hyaluronidases that digest HA in somatic tissues. The deposition of HA increases in the inflamed tissues in several inflammatory diseases, including Inflammatory Bowel Disease (IBD). This study provides evidence …
Effects Of Shear Stress On The Distribution Of Kindlins In Endothelial Cells, Sidney V. Jones
Effects Of Shear Stress On The Distribution Of Kindlins In Endothelial Cells, Sidney V. Jones
ETD Archive
Endothelial cells (ECs) are exposed to changes in shear stress under a variety of physiological and pathological circumstances and respond by changing their shape, gene expression and cytoskeletal arrangement. Integrins are central mediators of these mechanotransduction responses of ECs and integrin function is in turn controlled by interaction of their short cytoplasmic tails with cytoplasmic binding partners. Recent studies have demonstrated the importance of the kindlin family members, known cytoplasmic tail binding proteins, as regulators of integrin function. Our lab has previously shown that kindlin-2 (K2) and kindlin-3 (K3) are both expressed and functionally significant for integrin mediated cellular events …