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Articles 1 - 13 of 13
Full-Text Articles in Physical Sciences and Mathematics
Ccl2 (Mcp-1) Mediates Chronic Pelvic Pain Through Mast Cells In Experimental Autoimmune Cystitis, Fuat Bicer
Ccl2 (Mcp-1) Mediates Chronic Pelvic Pain Through Mast Cells In Experimental Autoimmune Cystitis, Fuat Bicer
ETD Archive
Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic inflammatory bladder condition with unknown pathophysiology. Chronic pelvic pain is one of the most important and disturbing symptoms of IC/PBS, beside urinary frequency, urgency, and nocturia. Increased amounts of mast cells (MCs) and CCL2 have been found in bladder tissue and urine, respectively. Whether or not there is a causal relationship between CCL2, MCs, and pelvic pain in IC/PBS is unknown. Methods: Female BALB/c mice were immunized with a peptide consisting of residues 65-84 of the bladder urothelium-specific protein uroplakin 3A to induce experimental autoimmune cystitis (EAC), a model for human IC/PBS. …
Chronic Kidney Disease: Vitamin D Treatment Regimens And Novel Assay Development For Kidney And Cardiovascular Function Biomarkers, Joe M. El-Khoury
Chronic Kidney Disease: Vitamin D Treatment Regimens And Novel Assay Development For Kidney And Cardiovascular Function Biomarkers, Joe M. El-Khoury
ETD Archive
Chronic kidney disease (CKD) is highly prevalent in the US population and has high incidence of cardiovascular and all-cause mortality. A known complication of CKD is secondary hyperparathyroidism that is caused by bone and mineral imbalances, including vitamin D deficiency. Supplementation of CKD patients with vitamin D is based on guidelines issued by the Kidney Disease Quality Outcomes Initiative (K/DOQI), which recommend administration of vitamin D2 in variable doses depending on the severity of vitamin D deficiency. Retrospective and pilot studies have shown that vitamin D2 was not as effective as vitamin D3 in treating vitamin D deficiency. In Chapter …
Gain-Of-Function Mutations In Scn5a Gene Lead To Type-3 Long Qt Syndrome, Fang Fang
Gain-Of-Function Mutations In Scn5a Gene Lead To Type-3 Long Qt Syndrome, Fang Fang
ETD Archive
Type-3 long QT syndrome, which is related to type 5 voltage-gated sodium channel alpha subunit (SCN5A) mutation, has been identified since 1995. LQTS mutation in SCN5A is a gain-of-function mutation producing late sodium current, INa,L. Brugada mutation in SCN5A is a loss-of-function causing INa decrease. Whereas, the mechanism for Dilated Cardiomyopathy mutations in SCN5A is still not fully understood. N1325S is one of the first series of mutations identified for type-3 LQTS. Our lab created a mouse model for LQTS by expressing SCN5A mutation N1325S in the mouse hearts (TG-NS) and a matched experimental control line with overexpression of wild- …
Development And Characterization Of Experimental Autoimmune Cystitis (Eac), Kenan Izgi
Development And Characterization Of Experimental Autoimmune Cystitis (Eac), Kenan Izgi
ETD Archive
Interstitial Cystitis/Painful Bladder Syndrome(IC/PBS) is a chronic inflammation of the urinary bladder, consisting of irritative voiding symptoms frequent and urgent urination and pain referred to the pelvic region or the bladder upon filling, lack of other pathology. The pathophysiology of interstitial cystitis (IC) is enigmatic. The impaired urothelium of bladder and autoimmunity might lead the underlying pathology. One of the shortcomings in IC/PBS research has been the lack of an appropriate animal model. In the current study, we show that the bladder specific Uroplakin 3A (UPK3A)-derived immunogenic UPK3A 65-84 peptide is capable of targeting experimental autoimmune cystitis (EAC) in BALB/c …
Characterization Of Pharmaceutical Materials By Thermal And Analytical Methods, Manik Pavan Kumar Maheswaram
Characterization Of Pharmaceutical Materials By Thermal And Analytical Methods, Manik Pavan Kumar Maheswaram
ETD Archive
No abstract provided.
Ellagic Acid-Mediated Ck2 Inhibition;A Natural, Multifunctional Strategy To Trigger Cervical Cancer Cell Death In Vitro And In Vivo, Hanan F. Mohammad
Ellagic Acid-Mediated Ck2 Inhibition;A Natural, Multifunctional Strategy To Trigger Cervical Cancer Cell Death In Vitro And In Vivo, Hanan F. Mohammad
ETD Archive
Targeting CK2 for cancer therapy has proven effective in inhibiting tumor growth in several histology's. The main goal of this study was to acquire pre-clinical data on a naturally occurring CK2-inhibitor (ellagic acid) in support of a human clinical trial. In vitro analysis included testing the spectrum of ellagic acid anti-cancer activity, defining the mode of growth inhibition in cancer cells and its impact on biochemical and molecular pathways. In vivo studies included determination of ellagic acid inhibitory effect in animal tumor models and toxicity analysis. We found that CK2 inhibition mediated by ellagic acid, was effective in inhibiting the …
Novel Solid State Properties Of Drugs, Polymers And Various Chemicals By Thermal And Analytical Techniques, Dhruthiman R. Mantheni
Novel Solid State Properties Of Drugs, Polymers And Various Chemicals By Thermal And Analytical Techniques, Dhruthiman R. Mantheni
ETD Archive
I have observed unique variations in AC electrical conductivity of solids by dielectric analysis (DEA or DETA) when studied with respect to temperature and frequency. A wide range of solids were examined for this study e.g. organics, polymers, carbohydrates, API's (active pharmacy ingredients) and amino acids. Experimental results clearly show novel dielectric behavior of a linear increase in a log ionic conductivity vs. temperature in the pre-melt (20 to 30oC below the melt temperature) and melt transition regions. We have differentiated the solids which show the conductivity variations in pre-melt from those which do not e.g. pre-melt conductivity variations observed …
Proteomic Approaches To Elucidate Molecular Mechanisms Of Metal Accumulation In Plants With Focus On Arsenic, Chamari Hasintha Walliwalagedara Kiribandage
Proteomic Approaches To Elucidate Molecular Mechanisms Of Metal Accumulation In Plants With Focus On Arsenic, Chamari Hasintha Walliwalagedara Kiribandage
ETD Archive
No abstract provided.
Design And Synthesis Of Antithrombotic Liposomal Protein Conjugate, Hailong Zhang
Design And Synthesis Of Antithrombotic Liposomal Protein Conjugate, Hailong Zhang
ETD Archive
Recent advances in the molecular bases of haemostasis have highlighted that endothelial thrombomodulin (TM) plays a critical role in local haemostasis by binding thrombin and subsequently converting protein C to its active form (APC). In addition, the binding of thrombin to TM drastically alters the thrombin's procoagulant activities to anticoagulant activities. The lipid bilayer in which it resides serves as an essential 'cofactor', locally concentrating and coordinating the appropriate alignment of reacting cofactors and substrates for protein C activation. On the other hand, liposomes have been extensively studied as cell membrane model as well as carrier for delivering certain vaccines, …
Rnase L Manipulates Macrophages In Innate Immunity And Tumor Growth, Xin Yi
Rnase L Manipulates Macrophages In Innate Immunity And Tumor Growth, Xin Yi
ETD Archive
RNase L is one of the key enzymes in the 2-5A system of interferon (IFN) action against viral infection and cellular proliferation. Tissue distribution analysis has revealed that RNase L is highly expressed in the spleen, thymus, lung, testis, intestine and most of immune cells such as T, B cells and macrophages. However, the physiological role of RNase L in the immune system is largely unknown. My thesis thus focused on studying the possible physiological role of RNase L in macrophages. By using bone marrow-derived macrophages (BMMs) from RNase L+/+and -/- mice, we demonstrated that RNase L is involved in …
Purification And Characterization Of Blood Aspirin Hydrolases, Gang Zhou
Purification And Characterization Of Blood Aspirin Hydrolases, Gang Zhou
ETD Archive
Aspirin prophylaxis suppresses major adverse cardiovascular events, but its turnover in blood is rapid, which limits its inhibitory effects on platelet cyclooxygenase and thrombosis. Inter-individual variability of platelet responses to aspirin clinically presents as treatment failure, and this increasing clinical phenomenon is frequently named aspirin "resistance". However, the molecular mechanisms behind this are unclear. Blood aspirin hydrolases are believed to control aspirin survival in vivo, but the identity of the circulating enzyme(s) that hydrolyzes aspirin remains unknown. In this thesis, blood aspirin hydrolases were identified and characterized. The relationship between blood aspirin hydrolases and aspirin efficacy was investigated. RP-HPLC analysis …
Boronic Acid Macroligands For Glycomics Applications, Poornima Pinnamaneni
Boronic Acid Macroligands For Glycomics Applications, Poornima Pinnamaneni
ETD Archive
Cell surface carbohydrates existing as glycoproteins and glycolipids represent the first information about the cell with the outside world and are closely involved in various biological processes such as cell communication, and the molecular recognition and cell targeting. However, the mechanisms of most of the processes at the molecular level are still unclear. It is therefore very important to develop specific carbohydrate-binding molecules for a fast, efficient, sensitive and accurate analysis of complex carbohydrates structures and functions, known as glycomics. In addition, certain carbohydrate-binding molecules can be used in medical applications such as biomarkers for diseases diagnosis and targeted drug …
Methylation Markers In Hepatocellular Carcinoma, Avinash Gavicharla
Methylation Markers In Hepatocellular Carcinoma, Avinash Gavicharla
ETD Archive
Hepatocellular Carcinoma is one of the major causes for mortality in the world and is usually asymptomatic until late stage decreasing the survival rate. There is an increase of incidence every year and current diagnostic and prognostic bio markers like AFP have their limitations in the wider context. Therefore, it is important to develop novel biomarkers. The aim of the Research is to understand the cytosine methylation and investigate the role of the p16 and SLIT-2 genes as biomarkers in Hepatocellular Carcinoma. The methylation profiles of the genes were assessed on bisulfite modified DNA samples with the aid of Real …