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Full-Text Articles in Physical Sciences and Mathematics
Paramagnetic Nuclear Magnetic Resonance (Nmr) Studies On The Calcium Binding Site Of [Alpha]-Lactalbumin, Thomas Kurt Ritter
Paramagnetic Nuclear Magnetic Resonance (Nmr) Studies On The Calcium Binding Site Of [Alpha]-Lactalbumin, Thomas Kurt Ritter
Dissertations and Theses
Paramagnetic NMR has drawn interest as a technique for extending the range of systems that can be investigated. The purpose of this study was to determine whether a combination of paramagnetic two-dimensional and relaxation techniques allows for assigning resonances corresponding to residues forming the metal binding site of proteins in which the metal is coordinated exclusively by amino acid side chains and which have been previously inaccessible to assignment.
α-Lactalbumin (LA) is a calcium binding protein with relatively broad NMR signals; this broadness has prevented complete assignment. LA has been the subject of many studies, because it can form a …
Xanthones As Antimalarial Agents : Binding Interactions Between Heme Analogues And Xanthones, Jane Xu Kelly
Xanthones As Antimalarial Agents : Binding Interactions Between Heme Analogues And Xanthones, Jane Xu Kelly
Dissertations and Theses
Human falciparum malaria is caused by Plasmodium falciparum parasite, which digests host hemoglobin within its food vacuole, releasing toxic heme. P. falciparum detoxifies free heme to hemozoin by polymerization. This process is believed to be the target of most successful antimalarial drugs, chloroquine and quinine, which are now losing their effectiveness due to the spread of multi-drug resistant strains. Xanthones were recognized in the laboratory of Dr. M. Riscoe (Portland VA Medical Center) to bind to heme, preventing heme polymerization [Ignatushchenko, M., Winter R., and Riscoe, M. (1997) FEBS Letters 409, 67].
This thesis reports a study of the interactions …
The Synthesis And Characterization Of A Porphyrin Oligomer As A Potential Antenna For Light Harvesting Solar Cells, Tristan Timothy Jenkins
The Synthesis And Characterization Of A Porphyrin Oligomer As A Potential Antenna For Light Harvesting Solar Cells, Tristan Timothy Jenkins
Dissertations and Theses
Mankind's attempts to harvest the sun have resulted in photocells with about 15% overall energy conversion efficiency. The best of these cells consist of a light-sensitive dye attached to a semiconductor. Absorbed light energy is transferred to the semiconductor via the delivery of an excited electron from the dye. Dye electrons are replenished with a redox solution, coupling the dye to the counter electrode.
This research was the beginning of an exploration into some potential improvements in the cell. First of all, the redox solution is a corrosive liquid, and leaks present a problem. A porphyrin oligomer with a TCPP …