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Chemical Modification Of Skeletal Muscle Sarcoplasmic Reticulum Vesicles: A Study Of Calcium Permeability, Janice F. Stuart
Chemical Modification Of Skeletal Muscle Sarcoplasmic Reticulum Vesicles: A Study Of Calcium Permeability, Janice F. Stuart
Dissertations and Theses
Skeletal muscle contains an internal membrane system called the sarcoplasmic reticulum (SR) whose function is to regulate the Ca2+ concentration of the myoplasm. Ca2+ is transported into the SR from the myoplasm via a Ca2+ dependent ATPase thus lowering the myoplasmic Ca2+ concentration. Ca2+ exits from the SR via a Ca2+ releqse pathway resultingin the increase of myoplasmic Ca2+. Muscles contract when the myoplasmic Ca2+ concentration is > 5 uM and relax when the Ca2+ concentration is lowered below 1 uM. The Ca2+ dependent ATPase has been extensively studied but …