Physical Sciences and Mathematics Commons^™

Development And Application Of A Gg-Irms Reductive Pyrolysis Reactor Interface For The Δ34S Determination Of Sulfur In Individual Organic Compounds, N. Deborah Hewlett

Chemistry & Biochemistry Theses & Dissertations

The incorporation of sulfur into sedimentary organic matter is an important aspect of organic carbon preservation. A better understanding of the sulfur cycle and the formation of organo-sulfur compounds are necessary if we are to better understand the interaction of biogeochemical cycles of C, N, O, H. and S. Currently, the determination of ³⁴S/³²S in organic matter is limited to bulk organic samples. The sulfur isotopic analysis of individual organo-sulfur compounds within the sediments should allow for a more complete understanding of the sulfur cycle and the processes which lead to sulfur incorporation into organic matter. This …

The Regioselective 3-Alkylation Of Piperidine, Richard Dunn Todd

Chemistry & Biochemistry Theses & Dissertations

The compounds: 3-allylpiperidine, 3-ethylpiperidine and 3-n-butylpiperidine have been synthesized by regioselectively alkylating the three position of piperidine. Piperidine was converted to N-chloropiperidine and then dehydrohalogenated to produce Δ¹-piperideine. The enamide anion was generated by adding solutions of Δ¹-piperideine to ethylmagnesium bromide or lithium diisopropylamide. Addition of alkylhalides produced 3-alkyl- Δ¹-piperideine which could be reduced or alkyllithiated to give 3-alkylpiperidines or 2,3-dialkylpiperidines respectively.

The yields of products were low and the reaction generated a continuum of mono- and di-alkylpiperidines and there was evidence that several dimeric piperideines were formed. The low yields were discussed in …

Synthesis Of Dihydroisoquinolines And Tetrahydroisoquinolines, John J. Schlager

Chemistry & Biochemistry Theses & Dissertations

Dihydroisoquinolines and tetrahydroisoquinolines are compounds which possess a variety of pharmacological activities. New easier methods of synthetic manipulations of these structures is of constant interest in the pharmaceutical industry.

This paper describes a new three step method of preparing 1-alkyl- and 1-aryl-tetrahydroisoquinolines from a tetrahydroisoquinoline. The synthesis involves the N-chlorination of tetrahydroisoquinoline followed by dehydrohalogenation with potassium superoxide. The reaction products are the dihydroisoquinolines. Overall yields range from 85-96%. The unsubstituted, 1-methyl-, and 1-phenyl-J,4-dihydroisoquinolines have been formed. Organometallation of the unsubstituted dihydroisoquinoline provides the 1-substituted tetrahydroisoquinoline. The 1-benzyl-, 1-n-butyl-, 1-ethyl-, 1-methyl-, and 1-phenyl-1,2,J,4-tetrahydroisoquinolines were prepared. The use of Grignard and …