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Full-Text Articles in Physical Sciences and Mathematics
Visible Light-Triggered Carbon Monoxide-Releasing Molecules, Marina Popova
Visible Light-Triggered Carbon Monoxide-Releasing Molecules, Marina Popova
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Carbon monoxide (CO) is now well established as one of the signaling molecules in higher organisms, including humans. Due to its physiological roles, CO is now accepted as a potential therapeutic agent. The use of CO gas has been studied in multiple clinical trials. Vasodilation, anti-inflammatory, anti-apoptotic, anti-proliferative and cytoprotective effects are just a few of the pharmacological actions attributed to CO gas in various models of diseases. Use of inhaled CO gas as a therapeutic has many limitations which necessitate the development of a new approach for CO delivery. In order to handle CO safely, compounds that release CO …
Carbon Monoxide On Demand: Light-Induced Co Release Of Flavonols, Stacey N. Anderson
Carbon Monoxide On Demand: Light-Induced Co Release Of Flavonols, Stacey N. Anderson
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Carbon monoxide (CO) is an extremely useful molecule with applications in industrial manufacturing, synthetic procedures as a C1 building block, and as a potential pharmaceutical to produce anti-inflammatory effects and vasodilation. However, the toxicity associated with CO has prevented its full utilization. In order to safely handle CO, compounds and molecules have been developed that act as storage materials for the gas. Ideal storage platforms only release CO upon stimulation via a trigger. Light activation is the most desirable trigger as it can be regulated in terms of the intensity and the wavelength of light used. The majority of light-induced …