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Investigations Of Prokaryotic Defense Systems, Hannah Domgaard
Investigations Of Prokaryotic Defense Systems, Hannah Domgaard
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Bacteria are constantly threatened with infection by mobile genetic elements (MGE) such as bacteriophage and plasmids. Bacteriophage and plasmids require the bacteria's cellular infrastructure to replicate their genomes. Rampant replication can lead to cell death which is one reason why bacteria have developed a diverse array of immune systems to prevent or limit infection. This thesis studies three types of bacterial immune systems, type IV-A CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeat –CRISPR associated), type V-A2 CRISPR-Cas systems, and Wadjet systems.
The type IV-A system lies adjacent to a dinG-like helicase gene. Research has shown that this system can target …