Physical Sciences and Mathematics Commons^™

Structural And Functional Characterization Of The Ldp3 (Vhz) Protein Tyrosine Phosphatase, Vyacheslav I. Kuznetsov

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Protein phosphorylation is as an important regulatory mechanism that controls a large number of physiologically important cellular processes. Proteins are phosphorylated on aliphatic (serine and threonine) as well aromatic (histidine and tyrosine) residues predominantly located on sterically accessible loops. Phosphorylation affects three- dimensional structures of proteins resulting in conformational changes which activate or deactivate enzymatic functions. Because of the ability of protein phosphorylation to modulate a multitude of diverse cellular processes, it became an appealing and promising target for drug therapy.

Attachment of phosphate is accomplished by kinases, whereas the removal of the phosphoryl group is performed by protein phosphatases. …