Physical Sciences and Mathematics Commons^™

Effect Of Iron Binding On The Ability Of Crocidolite To Cause Dna Single-Strand Breaks, Jeanne Ann Hardy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Fibrous carcinogens, such as crocidolite asbestos, are known to catalyze many of the same reactions as iron, namely O₂ consumption, generation of reduced oxygen species, and damage to DNA, such as strand breaks, and modifications of bases. Upon inhalation, fibers are also known to become coated with an iron-rich material. The mechanism by which this iron is bound to fibers in the lung is not known, and the effect of this additional iron on the reactivity of the fibers is also not well understood. The studies described here were undertaken to elucidate the abilities of crocidolite asbestos, in its …