Physical Sciences and Mathematics Commons^™

The Pharmacodynamics And Toxicodynamics Of Inotropic Drugs In Calves With Natural And Artificial Hearts, Scott D. Everett

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Inotropic support for the failing myocardium as the therapy for congestive heart failure (CHF) is intended to achieve an increase in cardiac output via positive responses in myocardial contractility and vasodilation. A novel approach to differentiate these two responses is the use of an animal with an implanted total artificial heart (TAH). Three inotropic drugs, dobutamine, enoximone, and pimobendan, were tested in eight animals with their natural heart intact and five animals implanted with a TAH. Baseline values of the TAH and natural heart (NH) were compared to determine their hemodynamic similarities. Each of the three drugs was given randomly …