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Articles 1 - 14 of 14
Full-Text Articles in Physical Sciences and Mathematics
Literature Search On Using Dendrimer Nanoparticles As Drug Delivery Vehicles, Sivateja Kasaraneni
Literature Search On Using Dendrimer Nanoparticles As Drug Delivery Vehicles, Sivateja Kasaraneni
All Capstone Projects
The architectural design of dendrimers, multivalency, well-defined molecular weight and higher degree of branching differentiates them as unique and excellent nanocarriers in therapeutic applications such as drug delivery, gene transfection, tumor therapy, imaging and diagnostics. Nanoparticle drug-delivery systems are well known to increase the stability and selectivity of therapeutic agents. However immunogenicity, reticuloendothelial system uptake, drug leakage, cytotoxicity, hemolytic toxicity, poor aqueous solubility restrict the use of these drug delivery systems. These defects are overcame by surface engineering of the dendrimer molecule.
Drug molecule can be efficiently conjugated or encapsulated into the interior of the dendrimer or physically adsorbed onto …
Quality Assurance Plan Project For Copper Determination Using Flame Atomic Absorption Spectroscopy, Bharath Raparthi
Quality Assurance Plan Project For Copper Determination Using Flame Atomic Absorption Spectroscopy, Bharath Raparthi
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This study developed a method for determination of Copper by flame atomic absorption spectrometry (FAAS) from the soil samples and mine tailings using Perkin Elmer AAnalyst 800 atomic absorption spectrometer. A detailed procedure has been developed with a detection limit of 0.12 mg/L. In the recent decades, pollution from heavy metals has been increased. Copper is one of the trace metals that has a significant impact and carries risk to the human health. Calibration curve was established with working range 0.1 ppm to 5 ppm with a correlation coefficient of 0.9994. Over 50 environmental samples from the historic Copper mining …
Evaluation And In Vitro Studies Of Folate Peg Biotin And Other Peg Agents, Syed Zahid Hussain
Evaluation And In Vitro Studies Of Folate Peg Biotin And Other Peg Agents, Syed Zahid Hussain
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Folate is a member of vitamin B family and plays an essential role in cell survival by participating in the biosynthesis of nucleic and amino acids. Receptors folic acid are frequently over expressed on epithelial cancer cells. These receptors are believed to serve as a receptor-mediated transport system of folic acid into cancer cells and cells associated with inflammation. Interesting, most normal cells in the body have lower frequency of these receptors. Based on these attributes, folate based drug delivery, imaging systems, and diagnostic systems are in several stages of development worldwide.
In this current project, we have characterized the …
Method For Arsenic Detection In Mine Samples From The Upper Peninsula Of Michigan, Vinay Babu Yalamanchili
Method For Arsenic Detection In Mine Samples From The Upper Peninsula Of Michigan, Vinay Babu Yalamanchili
All Capstone Projects
Arsenic is the 20th abundant element in the earth crust. High concentrations of Arsenic is seen in mine operating countries which can affect public health and biological environment. This may reach to drinking water through ground or surface run-off water. Long term exposure to arsenic causes cancer of bladder, skin, and lungs. So detecting the amount of arsenic in soil and drinking has been an analytical challenge. Arsenic is found in variety of chemical forms in organic and inorganic compounds which results in chemical and physical interferences in the analysis. Graphite Furnace Atomic Absorption Spectroscopy (GFAAS) was used to measure …
Purification And Analysis Of Folate-Dye Conjugate, Sravya Mothe
Purification And Analysis Of Folate-Dye Conjugate, Sravya Mothe
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Folate receptor has achieved great importance for use in targeted drug delivery and in vitro and in vivo diagnostic assays. Folate receptor (FR) is over expressed on several cancer cell types and activated macrophages, but exists in relatively low abundance on the surface of non-cancerous tissue and non-inflammatory cells. This unique attribute is the hallmark of folate – targeted methodologies allowing the diagnostic agent and/or drug to be ferried to the specific disease sites while preventing “off target” effects in normal tissues. Although several folate-based dyes have been reported, simple and detailed synthetic and purification methods for these conjugates have …
Nanoencapsulated Copper Pthalocyanine As Photodynamic Antimicrobial Chemotherapy, Prathima Arrabelly
Nanoencapsulated Copper Pthalocyanine As Photodynamic Antimicrobial Chemotherapy, Prathima Arrabelly
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The growing resistance developed by microbes towards antimicrobial agents has driven our focus on developing alternative treatment modalities such as Photodynamic antimicrobial chemotherapy (PACT). It would be difficult for the microbes to develop resistance towards singlet oxygen generated during the PACT process. Photosensitizers are the vehicles of the transfer and translation of light energy into a type II chemical reaction (singlet oxygen generation) in photodynamic antimicrobial chemotherapy. PACT is proposed as a potential, low cost approach to treatment of locally occurring infection.
Photodynamic inactivation (PDI) of Escherichia coli and Staphylococcus aureus has been studied in cultures treated with photoactivated copper …
Nano Encapsulated Drug Delivery For Biofilms, Arunakanth Chavala
Nano Encapsulated Drug Delivery For Biofilms, Arunakanth Chavala
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Biofilms are now considered ubiquitous in the natural world. Bacterial biofilms have been observed to be extremely heterogeneous, both structurally and with regard to the physiology of the bacterial cells within them. The prevailing conceptual model depicts bacterial biofilms as being made up of microcolonies, which serve as the basic unit of the greater biofilm structure. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. A number of elements in the process of biofilm formation have been studied as targets for novel drug delivery technologies. The present study aimed to penetrate biofilm by …
Analysis Of Barbiturates By Gc/Ms, Hplc And Chemical Ionization, Deepthi Ravipati
Analysis Of Barbiturates By Gc/Ms, Hplc And Chemical Ionization, Deepthi Ravipati
All Capstone Projects
Barbiturates are derivatives of barbituric acid. They act as central nervous depressants. These drugs are frequently used as sedatives or anesthetics. It is a simple and reproducible method for the analysis of barbiturates.
Usage of these drugs is increased in recent days and the analysis of barbiturates by GC/MS is very fast. As they are used as sedatives their usage has been increased to relieve the stress. But the over usage of these drugs may lead to death. Different barbiturates like phenobarbital, pentobarbital can be analyzed by their molecular weights. Because of the over usage of the drugs the interest …
Characterization Of Polymeric Phthalocyanine Nanoparticles Using Dynamic Light Scattering Laser, Satish Kumar Murarishetty
Characterization Of Polymeric Phthalocyanine Nanoparticles Using Dynamic Light Scattering Laser, Satish Kumar Murarishetty
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The objective of this study is to use DLS (Dynamic Light Scattering) to analyze polymeric copper phthalocyanine nanoparticles (CuPcNPs). CuPcNPs are synthesized in order to facilitate drug penetration of bacterial biofilms for the treatment of chronic wounds. Microorganisms that reside inside the biofilms of chronic wounds are very resistant to any kind of treatment, even to the host’s own immune system. Therefore we have proposed an alternative method to destroy the microorganisms existing within the biofilms. Photodynamic anti-bacterial chemotherapy (PACT) has received much attention for the past decade due to the multi-drug resistant strands. PACT uses photons, a photosensitizer, and …
Nih Shift Literature Search, Nicole Owens
Nih Shift Literature Search, Nicole Owens
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The NIH shift is a chemical shift of substituents in aromatic hydroxylation reactions. The substituents that undergo this shift are hydrogen, halogens, acyl and alkyl groups. It is an important aspect that is a requirement in the hydroxylation of aromatic compounds by monooxygenase enzymes.
The NIH shift or the National Institute of health shift gets its name from the founders of this mechanism. The National Institute of Health was the first to observe this phenomenon in there studies and are the first to report this chemical shift.
Nanoparticlated Drug Delivery System For Vitreous Humor, Kartheek K. Suragoni
Nanoparticlated Drug Delivery System For Vitreous Humor, Kartheek K. Suragoni
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The purpose of this study is to develop a unique nanoparticulated system that has the capability of providing sustained drug delivery into the eyes. In ophthalmic preparations, poor ocular drug delivery of ocular dosage form is due to the production of tears and impermeability through corneal epithelium. The usage of liposomes in ophthalmic disorders shows promising results in ocular drug delivery. Liposomes are bilayered, microscopic vesicles surrounded by the aqueous compartments. Liposomes have the ability to encapsulate both hydrophilic and hydrophobic drugs. This unique property of liposomes helps in delivering the drug at specific site. This invention involves three major …
Using Photoactive Nanoparticles As Photodynamic Antimicrobial Chemotherapeutic (Pact) Agent To Treat Chronic Wounds, Chaitanya Poola
Using Photoactive Nanoparticles As Photodynamic Antimicrobial Chemotherapeutic (Pact) Agent To Treat Chronic Wounds, Chaitanya Poola
All Capstone Projects
The purpose of this study is to use photoactive vitamin nanoparticles as photodynamic antimicrobial chemotherapeutic agent to treat patients with chronic wounds. Chronic wounds are considered as a pandemic health problem which affects millions of people and increases ~10 % annually. According to the American Academy of Dermatology, the expense of treating chronic wounds constitutes over half of the total cost for all skin diseases. The main cause of chronic wounds is due to the existence of biofilms. Biofilms are complex microbial communities containing and are reported to be major factor contributing to multiple chronic inflammatory diseases. Owing to bacterial …
Folate Nanoparticle Conjugates, Safwat A. Masood
Folate Nanoparticle Conjugates, Safwat A. Masood
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The folate receptor is overexpressed on the surface of numerous cancer cell types including those of the breast, lung, kidney, ovary, and brain. Recent interest has exploded in the use of folate to deliver payloads and imaging agents to folate receptor positive cancer cells based on several positive clinical trials including phase III trials of EC-145, which is poised to become the first folate targeted, FDA approved drug. Given the success of EC-145 and numerous other agents in the pharmaceutical pipeline, there remains a great interest in the exploitation of this technology in the delivery of nanoscale agents to folate …
Detection Of Folate Receptor From Fr+ Cells, Gopikrishna Pinnaka
Detection Of Folate Receptor From Fr+ Cells, Gopikrishna Pinnaka
All Capstone Projects
Targeted drug delivery is a newer and less explored arena that has potential scope in tumor targeting because the regular chemotherapy has lethal effects on the normal cells also. Our present Work was an attempt to specifically target receptors on cancerous cells, especially the Folate Receptor (FR). Folate is important for cells for DNA synthesis and the tissues that rapidly divide require folate, cancer cells are no exceptions for this. To cope with the increased demand for the folate the cancer cells express greater FR on the cell surface. This very fact was our basis for the construction of our …