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Full-Text Articles in Physical Sciences and Mathematics
Polycarbodiimides And Polyguanidines : Their Reactivity And Applications In Covalent Adaptable Networks, Alberto Melchor Bañales
Polycarbodiimides And Polyguanidines : Their Reactivity And Applications In Covalent Adaptable Networks, Alberto Melchor Bañales
Scholars Week
We have recently discovered a new chemical transformation in which N,N’,N’’ tri-substituted guanidines undergo a thermal exchange reaction. Kinetic investigations indicate that the transformation is first order with respect to the guanidine, indicating a dissociative mechanism in which a carbodiimide and amine are formed as intermediates. This new reaction has been applied to polymer systems. Polycarbodiimides were shown to undergo postpolymerization modification with amines to form polyguanidines at room temperature under an hour. Polyguanidines undergo the newly found chemical transformation to form different substituted polyguanidines. This exchange reaction will be applied to the preparation of a covalent adaptable network by …
Engineering Sortase; Activity And Selectivity Of New Hybrid And Ancestral Variants Of Sortase A, Sarah Struyvenberg
Engineering Sortase; Activity And Selectivity Of New Hybrid And Ancestral Variants Of Sortase A, Sarah Struyvenberg
Scholars Week
Bacterial sortase enzymes are a beneficial tool in innovative mechanisms of protein engineering. However, important limitations to utilization of sortases for engineered purposes exist; namely, that sortase A (SrtA) is a relatively poor enzyme and very specific for the substrate containing LPATXG motif. Exciting previous work from our collaborators reveals that sortases from different species recognize different sequences and that activity can vary. Therefore, we wanted to create and investigate hybrid sortase enzymes between SrtA from S. aureus and Streptococcus pneumoniae, wherein we swapped a substrate-interacting loop between the beta-E and beta-F strands. Our hypothesis is that these residues are …
Bottom-Up Shape Engineering Of Organic Molecular Single-Crystals, Griffin Reed
Bottom-Up Shape Engineering Of Organic Molecular Single-Crystals, Griffin Reed
Scholars Week
The ability to fabricate complex submicron-scale components from inorganic crystalline semiconductor materials such as c-Si enables countless modern technologies, from microelectromechanical systems to integrated circuits. For single-crystal molecular materials on the other hand, comparable approaches to defining micron- and submicron-scale structure are much less well developed, in part because weak intermolecular binding forces make molecular crystals vulnerable to damage by conventional techniques such as reactive ion etching, wet etching, and energetic beam milling. Here we show how the same weak forces that are problematic for top-down patterning of molecular crystals can be exploited to enable controlled bottom-up growth, by leveraging …