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Full-Text Articles in Physical Sciences and Mathematics
Development Of Bioorthogonal Molecular Tools On Gold Nanoparticles, Wilson Luo
Development Of Bioorthogonal Molecular Tools On Gold Nanoparticles, Wilson Luo
Electronic Thesis and Dissertation Repository
This thesis describes the development of bioorthogonal chemical tools — originally designed to form bonds cleanly and selectively in living systems — on gold nanoparticles (AuNPs) as a model reactive nanomaterial template to showcase chemical modifications in a facile and robust manner. To achieve this goal, new methodologies to cleanly incorporate strained alkyne (SA) and cargo-bearing triarylphosphine derivatives onto AuNPs were developed. The protocols described herein provide well-defined reactive AuNP interfaces that undergo bioorthogonal bond-forming and breaking reactions cleanly, selectively, and rapidly to enable chemical tuning of their properties and function.
In order to circumvent the high reactivity of SAs, …
Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen
Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen
Electronic Thesis and Dissertation Repository
Colloidal inorganic nanoparticles (NPs) have been attracting considerable interest in biomedicine, from drug and gene delivery to imaging, sensing and diagnostics. It is essential to modify the surface of nanoparticles to have enhanced biocompatibility and functionality for the in vitro and in vivo applications, especially in delivering locally and recognizing biomolecules. Herein, the goal of this research work is to develop advanced NPs with well-tailored surface functionalities and/or bio-functionality for the applications in cell tracking and analytes detection.
In the first project, quantum dots incorporating with gelatin nanoparticles (QDs-GNPs) have been developed for bioimaging applications. Two different approaches have been …