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Development Of Bioorthogonal Molecular Tools On Gold Nanoparticles, Wilson Luo
Development Of Bioorthogonal Molecular Tools On Gold Nanoparticles, Wilson Luo
Electronic Thesis and Dissertation Repository
This thesis describes the development of bioorthogonal chemical tools — originally designed to form bonds cleanly and selectively in living systems — on gold nanoparticles (AuNPs) as a model reactive nanomaterial template to showcase chemical modifications in a facile and robust manner. To achieve this goal, new methodologies to cleanly incorporate strained alkyne (SA) and cargo-bearing triarylphosphine derivatives onto AuNPs were developed. The protocols described herein provide well-defined reactive AuNP interfaces that undergo bioorthogonal bond-forming and breaking reactions cleanly, selectively, and rapidly to enable chemical tuning of their properties and function.
In order to circumvent the high reactivity of SAs, …