Physical Sciences and Mathematics Commons^™

The Development Of Metal-Organic Compounds For Use As Molecular Imaging Agents, Emily J. Simpson

Electronic Thesis and Dissertation Repository

Molecular imaging probes allow for the non-invasive diagnosis of many diseases through the use of a targeting entity for site specific delivery, as well as a signal for external visualization of probe accumulation in the body. This thesis will focus on the development of new approaches to synthesize targeting peptides and chelators for radionuclide incorporation towards the design of novel molecular imaging probes.

Histidine is a tridentate chelator that can be attached in a pendant fashion to a biomolecule in order to coordinate technetium-99m. Once coordinated, it forms a neutral complex that is capable of forming diastereomers with inverted stereochemistry …

Synthesis Of Carbohydrate Functionalized Dendrons For Use As Multivalent Scaffold And In Self-Assembled Structures, Namrata Jain

Electronic Thesis and Dissertation Repository

Carbohydrates are implicated in a large number of biological processes ranging from cell-cell interactions to bacterial and viral infection. Lectins are carbohydrate-binding proteins that are generally specific for certain sugars. However, typical carbohydrate–lectin interactions tend to have very low monomeric binding affinities. In many cases, the binding of saccharide ligands by protein receptors can be improved significantly through the attachment of multiple saccharide residues to a common support. Dendronized polymers constitute a class of macromolecules whose nanoscale size, rigidity, and functionality can be controlled with precision by tuning their molecular architecture. It is hypothesized that due to their large size …

The Application Of Novel Donor Acceptor Cyclopropanes In The Synthesis Of Linearly Fused Tricyclic Triazoles, Michelle E. Flisar

Electronic Thesis and Dissertation Repository

Previous work in the Kerr group has shown the success of donor-acceptor cyclopropanes as substrates in a variety of synthetic reactions; this document will apply the use of donor acceptor cyclopropanes in various synthetic reactions. This was done using a 2-substituted 1,1-cyclopropanediester, in the Overman Rearrangement, which has yet to be explored using DA cyclopropanes. Another useful DA cyclopropane is the novel acetylene-bearing donor acceptor diester cyclopropanes which would be synthetically useful in a wide variety of reactions. In particular, the Conia-ene cyclization occurred intramolecularly with this alkyne DA cyclopropane with a large library of nucleophiles. Finally, taking this acetylene-bearing …