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Degradation Kinetics And Functional Design Of Linear Self-Immolative Polymers, Ryan A. Mcbride
Degradation Kinetics And Functional Design Of Linear Self-Immolative Polymers, Ryan A. Mcbride
Electronic Thesis and Dissertation Repository
Linear self-immolative polymers display a potential to address many of the limitations in the control over the degradation process in traditional biodegradable polymers. These materials are unique relative to most degradable polymers, in that they undergo end-to-end depolymerization in response to the cleavage of a stabilizing end-capping agent. Although one of their cited attributes is a dependence of their degradation time on chain length, no conclusive study has been conducted to demonstrate and study this effect. Using a previously reported linear self-immolative backbone derived from alternating 4-hydroxybenzyl alcohol and N,N’-dimethylethylenediamine spacers, this work offers the first conclusive study demonstrating …