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The Roles Of Rhle And Hfq In Srna-Dependent Gene Regulation, Abeykoon Jayalath Iresha Sandeepanie Rathnayake
The Roles Of Rhle And Hfq In Srna-Dependent Gene Regulation, Abeykoon Jayalath Iresha Sandeepanie Rathnayake
Wayne State University Theses
THE ROLES OF RHLE AND HFQ IN SRNA-DEPENDENT GENE REGULATION
by
ABEYKOON JAYALATH IRESHA SANDEEPANIE RATHNAYAKE
DECEMBER 2010
Advisor: Dr. Andrew Feig
Major: Chemistry
Degree: Master of Science
Bacteria are adapted to live in diverse environmental conditions. Thus, they show excellent tolerance and response to extreme environmental conditions caused by low or high temperatures, high salinity, reactive oxygen species or high nutrient concentrations. sRNAs have been identified and characterized as cis-acting or trans-acting post-transcriptional regulators in diverse cellular processes including virulence and adaptation to environmental stress (11,12,14,15). Interactions of sRNAs and target mRNAs result in translational repression, translational activation or/and …