Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Physical Sciences and Mathematics
Synthesis And Biological Studies Of Amphiphilic Compounds Derived From Saccharides And Aminoglycosides, Madher N. Alfindee
Synthesis And Biological Studies Of Amphiphilic Compounds Derived From Saccharides And Aminoglycosides, Madher N. Alfindee
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Adjacent cells communicate through gap junctions (GJs). These GJs are formed by head to head docking of two hemichannels (HCs) from two adjacent cells. HCs are connexin hexamer proteins. Connexin mutation is the most frequent cause of childhood hearing loss. This hearing impairment affects 2 in every 2000 children. Inhibition of the HCs might be the key factor to treat such disorders. A library of amphiphilic kanamycins was synthesized to be tested as HC inhibitors. These compounds showed excellent inhibition activity in comparison with the parent compound (kanamycin A) with less toxicity.
A library of monosaccharide esters with varying carbon …