Physical Sciences and Mathematics Commons^™

Cost-Effective Synthesis, Bioactivity And Cellular Uptake Study Of Aminoglycosides With Antimicrobial And Connexin Hemichannel Inhibitory Activity, Yagya P. Subedi

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Amphiphilic kanamycin is one of the promising class of compounds for the treatment of fungal infections in plants and animal. Factor that lead to the restricting of compounds for commercialization includes, the higher cost of production and poor stability of the compound. However, the new lead, identified from the synthesis and biological testing, can be synthesized on a large scale with a cost comparable to commercial antifungals. The newly reported lead is stable at the acidic and basic conditions. Additionally, this compound has an excellent activity towards Candida auris, a multidrug-resistant superbug.

Heart disease is the leading cause of death …