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Structural And Functional Characterization Of The Essential Rna Helicase Mtr4, Ryan N. Jackson
Structural And Functional Characterization Of The Essential Rna Helicase Mtr4, Ryan N. Jackson
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
To insure the integrity of nuclear RNA, the eukaryotic cell employs surveillance systems that identify and degrade RNAs that are detrimental or unneeded. The failure of RNA surveillance systems can lead to neurodegenerative disease states and cancer. The essential RNA helicase Mtr4 is required for the degradation and processing of several nuclear RNAs. To further the understanding of RNA surveillance and processing in eukaryotes, Ryan Jackson of the Department of Chemistry and Biochemistry at Utah State University has determined the molecular structure of Mtr4 and has used this structure to interrogate Mtr4 function biochemically. The structure revealed that Mtr4 contains …