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Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of A Novel Carbon Monoxide-Releasing Gallium Flavonol Complex, Joel Ashton
Synthesis Of A Novel Carbon Monoxide-Releasing Gallium Flavonol Complex, Joel Ashton
Student Research Symposium
Carbon monoxide (CO) has unique therapeutic properties including anti-cancer effects. Flavonols such as 3-hydroxyflavone can release CO upon exposure to visible light. Gallium(III) also has anti-cancer properties and can replace Fe(III) in biological processes. This research was focused on synthesizing a complex of gallium(III) and 3-hydroxyflavone which can hopefully combine the anti-cancer properties of both gallium and CO. Initial attempts to synthesize the complex mimicked those of transition metal flavonol complexes using a base to deprotonate the flavonol and stirring with gallium salt. The most successful synthesis developed involved dissolving 3-hydroxyflavone and gallium nitrate in ethanol and DMSO, adjusting the …
Investigating Position 312 In Prmt1 For Future Fluorescent Labeling Studies, Sarah Nielson
Investigating Position 312 In Prmt1 For Future Fluorescent Labeling Studies, Sarah Nielson
Student Research Symposium
Protein arginine methyltransferase 1 (PRMT1) is an enzyme that post-translationally methylates other proteins in the cell. These methylation events play critical roles in maintaining cellular health. Labeling PRMT1 site-specifically will enable further research in PRMT1 oligomeric state in vivo and can be applied in future fluorescent studies. The intention of this research was to identify a position to label PRMT1 that does not affect oligomerization or activity. Position 312 was chosen as the site for specific tagging as it will have less interference in oligomerization, minimizes free rotation of fluorescent tags, and is surface-exposed. To confirm that position 312 was …
Can Superoxide-Responsive Co Delivery Molecules Be Developed?, Taylor Dittmar
Can Superoxide-Responsive Co Delivery Molecules Be Developed?, Taylor Dittmar
Student Research Symposium
Although known for its toxicity, carbon monoxide (CO) has now been identified as producing beneficial health effects when present at low concentrations. CO is generated in the human body during the breakdown of heme. It is known for its anti-cancer, cardioprotective, and anti-inflammatory effects. To enhance these therapeutic effects, CO delivery molecules have been developed. Fluorescent flavonol-based CO delivery molecules are gaining broad interest due to their triggerable, trackable, and targetable properties. Flavonols can also be used as dual functioning molecules, with additional capabilities such as the detection of reactive oxygen species (ROS) being possible to incorporate in addition to …
The Connections Between Musculoskeletal Injury And Global Reaction, Keaton Reel
The Connections Between Musculoskeletal Injury And Global Reaction, Keaton Reel
Student Research Symposium
The peripheral effects of severe musculoskeletal injury are a well-studied phenomenon, but less well studied are the neural deficits. Past research has demonstrated that such severe injuries, specifically torn and reconstructed anterior cruciate ligament (ACL), may increase cognitive burden due to lack of afferent feedback from damaged nerves. This has previously shown to lead to delayed voluntary reactions in the lower extremities, but global neural changes are currently unknown. The goal of the conducted research was to determine whether neuromuscular deficits due to ACL injury and reconstruction in one limb influences motor behavior on a global level. Simple reaction time, …
Air Quality Measurements In Ephraim, Ut, Alex Allred
Air Quality Measurements In Ephraim, Ut, Alex Allred
Utah Space Grant Consortium
Standard Air Quality indicators: NO, NOx, SO2, CO, O3 and PM2.5 were measured in Ephraim, Sanpete county, Utah from Dec 16, 2020 -Mar 6, 2021. The Air quailty monitoring station was installed in December 2020 and is currently operating. Ephraim is located in a high mountain valley at 5541 feet elevation. Events of interest were evaluated using back trajectories and wind rose analysis.
Evaluating Gallium As A Catalyst For Silicon Nanodot Synthesis, Rylan Woods
Evaluating Gallium As A Catalyst For Silicon Nanodot Synthesis, Rylan Woods
Utah Space Grant Consortium
Silicon nanostructures, such as silicon nanowires and silicon nanodots, exhibit notably different thermoelectric, electric, and optical properties from bulk silicon. These nanostructures are ideal for utilization in a variety of electronic and optical devices ranging from batteries to solar panels. While various synthesis methods and catalysts exist for making silicon nanowires, gallium exhibits unique nanowire shapes compared to other catalyst metals such as gold or silver. This experiment uses gallium as a catalyst to form silicon nanostructures onoriented silicon substrate at temperatures of 0, 850, and 900ºC. Analyzing dosed samples via SEM resulted in several samples showing possible evidence of …