Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- 1 (1)
- 1 3-Dioxolane (1)
- 2-CP = 2-Clip-phen (1)
- 2-cis-diaminocyclohexane (1)
- Asymmetric synthesis (1)
-
- Biochemistry (1)
- Biocomputational Method (1)
- CD = Circular dichroism (1)
- Chemistry (1)
- Chiral resolution (1)
- Coincidence (1)
- Crown ether (1)
- Enzymatic resolution (1)
- FID = Fluorescent intercalator displacement (1)
- G4 = G-quadruplex (1)
- Henry Reaction (1)
- ITC = Isothermal titration calorimetry (1)
- Methyl vinyl ketone (1)
- Organic Chemistry (1)
- Organic chemistry (1)
- PEPICO (1)
- Pharmaceutical sciences (1)
- Photoionization (1)
- Structural Biology (1)
- TRAP = Telomeric repeat amplification protocol (1)
- Publication
- Publication Type
Articles 1 - 6 of 6
Full-Text Articles in Physical Sciences and Mathematics
In Silico Apc/C Substrate Discovery Reveals Cell Cycle-Dependent Degradation Of Uhrf1 And Other Chromatin Regulators, Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele
In Silico Apc/C Substrate Discovery Reveals Cell Cycle-Dependent Degradation Of Uhrf1 And Other Chromatin Regulators, Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele
College of the Pacific Faculty Articles
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle progression. Despite its vital role, it has remained challenging to globally map APC/C substrates. By combining orthogonal features of known substrates, we predicted APC/C substrates in silico. This analysis identified many known substrates and suggested numerous candidates. Unexpectedly, chromatin regulatory proteins are enriched among putative substrates, and we show experimentally that several chromatin proteins bind APC/C, oscillate during the cell cycle, and are degraded following APC/C activation, consistent with being direct APC/C substrates. Additional analysis revealed detailed mechanisms of ubiquitylation for UHRF1, a key chromatin …
Optical Properties And Composition Of Viscous Organic Particles Found In The Southern Great Plains, Matthew Fraund, Daniel Bonanno, Swarup China, Don Q. Pham, Daniel Veghte, Johannes Weis, Gourihar Kulkarni, Ken Teske, Mary K. Gilles, Alexander Laskin, Ryan C. Moffet
Optical Properties And Composition Of Viscous Organic Particles Found In The Southern Great Plains, Matthew Fraund, Daniel Bonanno, Swarup China, Don Q. Pham, Daniel Veghte, Johannes Weis, Gourihar Kulkarni, Ken Teske, Mary K. Gilles, Alexander Laskin, Ryan C. Moffet
Department of Chemistry Student Articles
Atmospheric high-viscosity organic particles (HVOPs) were observed in samples of ambient aerosols collected in April and May 2016 in the Southern Great Plains of the United States. These particles were apportioned as either airborne soil organic particles (ASOPs) or tar balls (TBs) from biomass burning based on spetro-microscopic imaging and assessments of meteorological records of smoke and precipitation data. Regardless of their apportionment, the number fractions of HVOPs were positively correlated (R2=0.85) with increased values of absorption Ångström exponent (AAE) measured in situ for ambient aerosol at the site. Extending this correlation to 100 % HVOPs yields an …
Kras Ubiquitination At Lysine 104 Retains Exchange Factor Regulation By Dynamically Modulating The Conformation Of The Interface, Guowei Yin, Jerry Zhang, Vinay Nair, Vinh Truong, Angelo Chaia, Johnny Petela, Joseph S. Harrison, Alemayehu A. Gorfe, Sharon L. Campbell
Kras Ubiquitination At Lysine 104 Retains Exchange Factor Regulation By Dynamically Modulating The Conformation Of The Interface, Guowei Yin, Jerry Zhang, Vinay Nair, Vinh Truong, Angelo Chaia, Johnny Petela, Joseph S. Harrison, Alemayehu A. Gorfe, Sharon L. Campbell
College of the Pacific Faculty Articles
RAS proteins function as highly regulated molecular switches that control cellular growth. In addition to regulatory proteins, RAS undergoes a number of posttranslational modifications (PTMs) that regulate its activity. Lysine 104, a hot spot for multiple PTMs, is a highly conserved residue that forms key interactions that stabilize the RAS helix-2(H2)/helix-3(H3) interface. Mutation at 104 attenuates interaction with guanine nucleotide exchange factors (GEFs), whereas ubiquitination at lysine 104 retains GEF regulation. To elucidate how ubiquitination modulates RAS function, we generated monoubiquitinated KRAS at 104 using chemical biology approaches and conducted biochemical, NMR, and computational analyses. We find that ubiquitination promotes …
Exploration Of Cis-1,2-Diaminocyclohexane-Based Conformationally Locked Chiral Ligands In Asymmetric Synthesis, Carim Van Beek
Exploration Of Cis-1,2-Diaminocyclohexane-Based Conformationally Locked Chiral Ligands In Asymmetric Synthesis, Carim Van Beek
University of the Pacific Theses and Dissertations
Natural products have been demonstrated to be of great significance to the pharmaceutical industry in the development of new drugs and medicine. Unfortunately, synthetic approaches to obtain these natural products often prove increasingly challenging due to the complexity of synthesizing the target drug in the proper stereochemistry. The availability of enantioselective reactions can play a pivotal role in overcoming this challenge, yielding access to optically pure intermediates and products. Chiral ligands based on a trans-1,2-diaminocyclohexane motif are often employed for this purpose and their complexes with transition metals have been demonstrated to act as efficient chiral catalysts in asymmetric reactions. …
Studies On The Size And Non-Planarity Of Aromatic Stacking Moiety On Conformation Selectivity And Thermal Stabilization Of G-Quadruplexes, Mandeep Singh
University of the Pacific Theses and Dissertations
Targeting DNA has the advantage over proteins for cancer remediation because of the fewer copies of the ligands required for the desired therapeutic effect. Traditionally, covalent DNA binders like alkylating agents have been used to induce genetic instability through the formation of DNA lesions and strand breaks, leading to cellular apoptosis. The primary drawback of this treatment is the non-specific binding that affects both cancerous and non-cancerous cells. G-quadruplexes are the DNA secondary structures that are present in abundance near the promoter regions of the oncogenes and are involved in the regulation of their activities. A ligand-mediated stabilization of G-quadruplexes …
Elephant And Anchors ‒ Photoelectron Photoion Coincidence Spectroscopy Of Small Oxygenated Molecules, Apeter Weidner
Elephant And Anchors ‒ Photoelectron Photoion Coincidence Spectroscopy Of Small Oxygenated Molecules, Apeter Weidner
University of the Pacific Theses and Dissertations
The dissociative photoionization reactions of two small, oxygenated organics, namely 1,3-dioxolane and methyl vinyl ketone, were studied by photoelectron photoion coincidence (PEPICO) spectroscopy. Experiments involving 1,3-dioxolane were carried out in the photon energy range of 9.5‒13.5 eV. The statistical thermodynamics model shows that a total of six dissociation channels are involved in the formation of three fragment ions, namely C3H5O2+ (m/z 73), C2H5O+ (m/z 45) and C2H4O+ (m/z 44), with two channels contributing to the formation of each. By comparing the results of ab initio quantum chemical calculations to the experimentally derived appearance energies of the fragment ions, the most …