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Full-Text Articles in Physical Sciences and Mathematics
Intracellular Zinc Trafficking: An Interplay Of Proteome, Metallothioneine And Glutathione, Afsana Mahim
Intracellular Zinc Trafficking: An Interplay Of Proteome, Metallothioneine And Glutathione, Afsana Mahim
Theses and Dissertations
Zinc is the second most abundant transition metal in living organisms. Typically, a eukaryotic cell contains approximately 3000 zinc binding proteins, in which zinc plays structural or catalytic roles. Recently, zinc has been reported to have signaling functions as a secondary messenger. Considering the diverse cellular functions of zinc, the trafficking pathways that help zinc, following its uptake into cytosol, find the target proteins and generate native Zn-Proteins are not well-understood. For past few decades, metallothionein, a zinc binding protein with large stability constants for Zn2+, has been thought of as a mediator in transferring zinc to apo-Proteins. However, gene …
The Role Of Proteome In Cellular Zn2+ Trafficking And In The Ability Of The Fluorescent Zinc Sensors To Image Intracellular Zn2+, Mohammad Rezaul Karim
The Role Of Proteome In Cellular Zn2+ Trafficking And In The Ability Of The Fluorescent Zinc Sensors To Image Intracellular Zn2+, Mohammad Rezaul Karim
Theses and Dissertations
Zinc is an essential biological trace metal used in as many as 3000 Zn-proteins, about 10% of the eukaryotic proteome, as either a structural constituent or a catalytic cofactor. These proteins include the zinc fingers, the most prevalent transcription factors that bind a wide range of gene promoters and thus regulate gene expression. A eukaryotic cell contains several hundred micromolar of Zn2+- almost all of it is bound to specific Zn-proteins. Recently, Zn2+ has been reported to serve as a regulatory signal and a neurotransmitter, suggesting that there also exists a dynamic Zn2+ pool in cells. These findings led to …