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Ibuprofen As A Probe Of Lipid Metabolism, Jose Antonio Rosales
Ibuprofen As A Probe Of Lipid Metabolism, Jose Antonio Rosales
Open Access Theses & Dissertations
The hypothesis that deracemization of racemic ibuprofen (IBU) occurs via the enolization of a Candida rugosa lipase (CRL)-ibuprofen ester (Scheme 1.6.2) was disproven by reacting racemic IBU under the conditions that were used to deracemize ibuprofen methyl ester (IME), namely pH 7.6. At pH 7.6, IME through IBU butyl esters were not formed in-situ and racemic IBU was not deracemized by reacting the corresponding primary alcohol with racemic IBU in the presence of CRL.
At pH 7.6, hexyl through dodecyl IBU esters were formed in-situ by reacting the corresponding primary alcohol with racemic IBU in the presence of CRL. The …