Physical Sciences and Mathematics Commons^™

Development And Application Of Synthetic Lipid Probes To Study And Mimic Lipid Function, Heidi Elizabeth Bostic

Doctoral Dissertations

Lipids are biologically important molecules as they regulate a litany of key cellular processes that, when aberrant, result in disease. Since lipids control these regulation pathways, it is imperative to understand their properties and exploit them for use in advancing therapeutic strategies. The complex environments in which lipids exist have historically complicated their understanding, but recent advancements have facilitated this effort. In the chapters that follow, we have used synthetic lipid probes to investigate the role of signaling lipids as site-specific ligands in the binding of protein effectors and developed a high-throughput platform that can be used to rapidly classify …