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Full-Text Articles in Physical Sciences and Mathematics
Construction Of Giant 2d And 3d Metallo-Supramolecules Based On Pyrylium Salts Chemistry, Yiming Li
Construction Of Giant 2d And 3d Metallo-Supramolecules Based On Pyrylium Salts Chemistry, Yiming Li
USF Tampa Graduate Theses and Dissertations
Pyrylium salts are a type of six-membered cationic heterocycles with one positively charged oxygen atom. Since the discovery of pyrylium salts in 1911, such salts have been underappreciated for a long time. Until 1960s, the importance of pyrylium salts has been realized as versatile precursors in a variety of organic syntheses. Due to their high reactivity towards various nucleophiles, pyrylium salts were widely used for the convenient synthesis of diverse heterocyclic compounds. Starting from 1980s, the high reactive feature of pyrylium salts were further utilized to synthesize viologen polymers with pyridinium salts in the backbones. During the past two decades, …
Self-Assembly Of 2d And 3d Metallo-Supramolecules With Increasing Complexity, Bo Song
Self-Assembly Of 2d And 3d Metallo-Supramolecules With Increasing Complexity, Bo Song
USF Tampa Graduate Theses and Dissertations
Synthetic organic chemistry played a crucial role in the construction of molecules through the formation and dissociation of covalent bonds. However, the laborious synthetic procedures as well as the low yield after multiple steps have restricted the pursuit of complicated giant molecules with high efficiency. Being complementary to organic synthesis, self-assembly provided an alternative route to achieving the giant architectures using weak non-covalent interactions in high efficiency, which is in analog to natural systems such as DNA, peptide, and protein. Among the various interactions, coordination has shown unique advantages in terms of directionality, reversibility and strength. Serving as a bottom-up …
Design, Synthesis, And Self-Assembly Of Supramolecular Fractals Based On Terpyridine With Different Transition Metal Ions, Lei Wang
USF Tampa Graduate Theses and Dissertations
Fractals have existed in a variety of natural forms, and the concept of "fractal geometry" has been developed in many areas by humankind, including art, economics, mathematics, physics, chemistry, material science, and etc. In the field of chemistry, researchers have endeavored great efforts to express the concept using molecules either by theoretical prediction or using synthetic methods in the past few decades, and one successful example is the “Sierpiński triangle”. Challenge still remains to achieve other fractal geometries as well as high generation of fractals with precisely controlled shape and size. Coordination-driven self-assembly has witnessed a wide array of well-defined …
Elastin-Like Polypeptide Fusion Tag As A Protein-Dependent Solubility Enhancer Of Cysteine-Knot Growth Factors, Tamina L. Johnson
Elastin-Like Polypeptide Fusion Tag As A Protein-Dependent Solubility Enhancer Of Cysteine-Knot Growth Factors, Tamina L. Johnson
USF Tampa Graduate Theses and Dissertations
Elastin-like peptide (ELP) fusions promote therapeutic delivery and efficacy. Recombinant proteins, like neurotrophins, lack bioavailability, have short in vivo half-lives, and require high manufacturing costs. Fusing recombinant proteins with genetically encodable ELPs will increase bioavailability, enhance in vivo solubilization, as well as provide a cost-effective method for purification without the need for chromatography. During expression of neurotrophin-ELP (N-ELP) fusions, dense water-insoluble aggregates known as inclusion bodies (IBs) are formed. Inclusion bodies are partially and misfolded proteins that usually require denaturants like Urea for solubilization. Strong denaturants arrest ELPs stimuli-responsive property and increase unwanted aggregation, making purification difficult, yet possible. The …