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Full-Text Articles in Physical Sciences and Mathematics
A Behavioral And Voltammetric Study Of The Effects Of Pb Exposure In Mice As A Model Of Autism Spectrum Disorder, Brenna Parke
A Behavioral And Voltammetric Study Of The Effects Of Pb Exposure In Mice As A Model Of Autism Spectrum Disorder, Brenna Parke
Theses and Dissertations
Despite being a known toxin for several centuries, lead (Pb2+) is still utilized in commercial products including leaded gasoline, paint, and modern cosmetics. This presence has caused (Pb2+) to pollute the environment, including public drinking water sources. The recent outbreaks of elevated levels of (Pb2+) in the drinking water in Flint, Michigan and Washington D.C. have caused large populations to be exposed to the heavy metal for months at a time, raising a public health concern over the implications of widespread, long-term (Pb2+) exposure. Young children are most susceptible to the effects …
Ultra-Fast Sensors To Study The Fundamental Neurochemistry Underlying Disease, Alyssa West
Ultra-Fast Sensors To Study The Fundamental Neurochemistry Underlying Disease, Alyssa West
Theses and Dissertations
Serotonin is a vital neurotransmitter whose exact roles are ill-defined. Dysfunctions in serotonin signaling are thought to underlie a myriad of neurological problems including depression and autism spectrum disorder (ASD). Prior to investigating serotonin’s role in disease states, one must understand more about the functionality of serotonin in healthy in vivo models. To study serotonin in vivo, fast-scan cyclic voltammetry (FSCV) and fast- scan controlled adsorption voltammetry (FSCAV) are employed to measure evoked and basal serotonin concentration, respectively. These methods, combined with mathematical modeling, provide information regarding regulatory mechanisms of serotonin neurotransmission. FSCV and FSCAV are first applied to …