Physical Sciences and Mathematics Commons^™

Structural And Functional Studies On 4-Hydroxy- Tetrahydrodipicolinate Reductase: Potential Drug Target In Bacteria, Swanandi Pote

Theses and Dissertations

Antimicrobial resistance has become an alarming public health concern since early 2000’s. Infections caused by multidrug resistant bacteria not only increase the mortality rate but also increase the economic burden globally. One approach to alleviate this issue is to find novel drug targets. In this regard, the bacterial lysine biosynthesis pathway provides several targets that may be used for design of antimicrobial compounds. Bacteria use lysine or meso-diaminopimelate to crosslink the peptidoglycan monomers in the bacterial cell wall. As such, we hypothesize that blocking this pathway will induce defects in the bacterial cell wall that are similar to those …