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Full-Text Articles in Physical Sciences and Mathematics
N-Methylation Of Amphetamine By Phenylethanolamine N- Methyltransferase: Implications For Chronic Therapeutic Use, Mackenzie Pavlik
N-Methylation Of Amphetamine By Phenylethanolamine N- Methyltransferase: Implications For Chronic Therapeutic Use, Mackenzie Pavlik
Master's Theses
In current forensic analysis, the presence of methamphetamine in a sample is routinely presumed to reflect methamphetamine abuse. This is due to the expectation that individuals either abusing, or receiving amphetamine for therapeutic purposes (e.g. as treatment for ADHD) will not generate any significant levels of methamphetamine as a product of metabolism. We have hypothesized however, that because amphetamine can serve as a substrate for methylation by phenylethanolamine n-methyltransferase (PNMT), (which will be in equilibrium with the reverse demethylation reaction) some individuals chronically taking amphetamine for therapeutic purposes may generate low levels of methamphetamine that would show up on a …
Determining The Interference Of Lactate And Lactate Dehydrogenase In An Ethanol Enzyme Assay, Julia Liebl
Determining The Interference Of Lactate And Lactate Dehydrogenase In An Ethanol Enzyme Assay, Julia Liebl
Master's Theses
Enzymatic ethanol assays are widely used to determine blood alcohol content for individuals admitted to a hospital. In some instances, this hospital data is later used as evidence in a court of law, most commonly in DUI cases. As the enzymatic assay targets, but does not exclusively measure ethanol, it is theoretically possible that interference could occur and produce a falsely elevated result, leading to wrongful convictions or other consequences. This project examined the potential of clinically relevant levels of one potential interferant, lactate and the hepatic enzyme lactate dehydrogenase (LDH) to cause significant and falsely elevated results. Threshold levels …