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Full-Text Articles in Physical Sciences and Mathematics

A Conceptual Understanding Of Concepts In Organic Chemistry, Timerra Chisham May 2024

A Conceptual Understanding Of Concepts In Organic Chemistry, Timerra Chisham

Theses/Capstones/Creative Projects

As students continue to make the transfer into organic chemistry from general chemistry, they will have to adjust to the new type of thinking required so that they will not fall behind in understanding material and will have success in the course. For this research project, I explored which concepts taught in organic chemistry are the most difficult for students to grasp. I had two main goals for this project. The first one is the central idea that I focused on, which was to see which concepts that have been taught in Organic Chemistry 1 the students are most confident …


The Effects Of Prior Calculus Classes On Success In Organic Chemistry, Tori Williamson May 2023

The Effects Of Prior Calculus Classes On Success In Organic Chemistry, Tori Williamson

Theses/Capstones/Creative Projects

Within University of Nebraska – Omaha (UNO) chemistry-based degree programs, organic chemistry along with at least two semesters of calculus are required courses. There is, however, no requirement for the order in which these courses should be taken. This is mainly due to the notion that for chemistry courses, organic chemistry is detached from the typical quantitative concepts studied in other chemistry-based courses. This is untrue, however, as many organic chemistry concepts rely on three-dimensional spatial visualizations and manipulations. Spatial awareness skills are strengthened within higher-level calculus classes. A survey was administered to organic chemistry students enrolled in 2022-2023. The …


The Impact Of Glacial Proximity On The Elemental Composition Of Leachate Derived From Sediment Weathering, Karoline Ford May 2023

The Impact Of Glacial Proximity On The Elemental Composition Of Leachate Derived From Sediment Weathering, Karoline Ford

Theses/Capstones/Creative Projects

This study assesses chemical weathering trends as they relate to glacial retreat. The chemical environment of surfaces exposed to the atmosphere differs significantly from beneath a glacier. As a glacier melts, changes to the biogeochemical processes generate environmental gradients. This study analyzed chemical weathering signals at different distances from a glacial front by comparing the elemental composition of leachate derived from sediments in southeastern Greenland. Samples from proglacial, nonglacial, and moraine locations were weathered in a laboratory setting, and ion chromatography was used to determine the elemental composition of the products. Divergent trends in leachate composition were observed as distance …


The Impact Of Service-Learning On General Chemistry Ii Students At The University Of Nebraska At Omaha, Kayla Rud May 2021

The Impact Of Service-Learning On General Chemistry Ii Students At The University Of Nebraska At Omaha, Kayla Rud

Theses/Capstones/Creative Projects

Service-learning has been shown to enhance academic and leadership skills while promoting community engagement and exposing students to different career opportunities (Esson et al., 2005). While the benefits of service-learning courses are clear, few STEM courses include service-learning components (Esson et al., 2005). Here, students in a totally online 2nd semester UNO chemistry course completed a service-learning project where they remotely led a live, inquiry-based STEM activity for Girl Scouts. To quantify the impact of service-learning on professional development, future career plans, and future volunteerism, a series of pre and post surveys were administered. Paired-sample t-tests revealed a statistically significant …


Characterization Of The Dimerization Domains On The Mannose-6-Phosphate/Insulin-Like Growth Factor Ii Receptor, Tyler Degener Dec 2019

Characterization Of The Dimerization Domains On The Mannose-6-Phosphate/Insulin-Like Growth Factor Ii Receptor, Tyler Degener

Theses/Capstones/Creative Projects

The mannose-6-phosphate/insulin-like growth factor II (M6P/IGF2) receptor is a transmembrane protein known to sequester growth factors from the extracellular matrix. This behavior suggests a mechanism of tumor suppression. Structurally, the receptor’s extracellular region is segmented into 15 homologous repeats, which are divided further into 5 triplet domains, labelled 1-3, 4-6, 7-9, 10-12, and 13-15. What is notable about the triplets is their propensity to form dimers with triplets on a second M6P/IGF2 receptor. In fact, previous studies indicate that this protein functions optimally when dimerized. Thus, the purpose of this experiment is to characterize these domain interactions. Using a urea …


Examining Electrochemical Properties Of O-Quinone And Sulfur Adducts Using Bisphenol A-3,4-Quinone Platform, Barbara Mullen May 2019

Examining Electrochemical Properties Of O-Quinone And Sulfur Adducts Using Bisphenol A-3,4-Quinone Platform, Barbara Mullen

Theses/Capstones/Creative Projects

o-Quinones are toxic electrophiles that can disrupt cellular macromolecules. Whether endogenous or xenobiotic, o-quinones are reactive compounds that are difficult to isolate. This work uses the o-quinone of bisphenol(BPA), bisphenol A-3,4-quinone(BPAQ), which can be efficiently synthesized and isolated, to study the electrochemical properties of o-quinones and their sulfur adducts in order to understand their metabolic fate. Cyclic voltammetry and equilibrium analysis were used to determine the relative oxidation potential of the BPA catechol and adducts, formed by reacting glutathione(GSH) and N-acetylcysteine(NAC) with BPAQ. BPAQ-sulfur adducts with 5-position substitution displayed lower oxidation potentials when compared to the …


Detection And Assay Of Isoniazid Utilizing Isocratic High-Performance Liquid Chromatography, Cassandra Nguyen May 2018

Detection And Assay Of Isoniazid Utilizing Isocratic High-Performance Liquid Chromatography, Cassandra Nguyen

Theses/Capstones/Creative Projects

To demonstrate an analysis for isoniazid from aqueous mixtures and solid tablets, utilizing isocratic conditions, with high performance liquid chromatography (HPLC) and UV detection. Isoniazid in solid and liquid samples is assayed utilizing HPLC. Isoniazid is a tuberculostat, that is assayed by high performance liquid chromatography that utilizes a reversed-phase C-18 column. The eluent solvent is 5.3% ethanol, 93.7% water, and 1% acetic acid. Aqueous samples are prepared in distilled water as the solvent. The ultraviolet-visible detection of isoniazid is accomplished at 265 nm, which is the wavelength having the highest sensitivity for isoniazid. Having a column pump pressure at …