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Articles 1 - 5 of 5
Full-Text Articles in Physical Sciences and Mathematics
Development Of The Regenerative Glycosylation Approach For Manual And Automated Oligosaccharide Synthesis, Swati Sudhir Nigudkar
Development Of The Regenerative Glycosylation Approach For Manual And Automated Oligosaccharide Synthesis, Swati Sudhir Nigudkar
Dissertations
It has been recognized that carbohydrates are involved in all phases of life beginning with the embryonic development and cell growth. However, it is the involvement of carbohydrates in the progression of various deadly diseases that gave these natural compounds significant roles in diagnostics and as pharmaceuticals. Although carbohydrates are highly desirable to the biological and medical communities, these molecules are still very challenging targets for chemists. Functionalization, derivatization, controlling anomeric stereoselectivity, purification, and characterization are all existing experimental hurdles towards producing synthetic carbohydrates in large quantities and high purity. Advances in chemistry and biochemistry have certainly facilitated the synthesis …
Soluble Amyloid-Beta 42 Aggregates Stimulate Cellular Inflammation Independent Of Cd47, Sanjib Karki
Soluble Amyloid-Beta 42 Aggregates Stimulate Cellular Inflammation Independent Of Cd47, Sanjib Karki
Dissertations
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the accumulation and deposition of aggregated amyloid-β protein (Aβ). Most of the studies indicate that Aβ1-42) and Aβ(1-40) play an important role in the neurodegenerative pathology in AD. A critical component of AD pathology is inflammation, which results from the activation of glial cells around the Aβ deposits. The goal of my dissertation research was to determine the role of Aβ aggregation in microglia-triggered inflammation and identify cellular components that mediate the inflammatory response. CD47 is a cellular receptor found on the microglia surface and it has been proposed to have …
Picolinyl-Assisted Approaches To Stereocontrolled Glycosylation, Jagodige Prithika Yasomanee
Picolinyl-Assisted Approaches To Stereocontrolled Glycosylation, Jagodige Prithika Yasomanee
Dissertations
Although carbohydrates are the most abundant molecules on Earth, our current knowledge of these fascinating natural compounds is still limited. Some aspects that are already known include the carbohydrate involvement in damaging cellular processes such as bacterial and viral infections, development of tumors, metastasis, septic shock, etc. Consequently the development of effective methods for the synthesis, isolation, analysis, and investigation of complex carbohydrates has become critical in all areas of glycoscience. Among various focus areas, stereocontrolled glycosylation has emerged as a topic of particular importance. Yet, it remains a remarkable challenge to chemists because a new chirality center is formed …
Understanding Mechanistic Details Of Neuroinflammatory Pathways Stimulated By The Alzheimer's Disease Amyloid-Beta Protein, Shana Usery
Dissertations
Alzheimer’s disease (AD) is characterized by neuroinflammation. Senile plaques composed of aggregated amyloid-β protein (Aβ) are found in AD patients’ brains. The Aβ is formed by the proteolytic cleavage of the amyloid precursor protein (APP) resulting in Aβ fragments that are 39-42 amino acids in length. The two most common peptides are Aβ(1-40) and Aβ(1-42), which differ by two amino acids, isoleucine and alanine. Within the brain of AD patients, Aβ monomer self-assembles to form several aggregate morphologies, including oligomers, protofibrils, and fibrils. Activated microglial cells and associated secreted proinflammatory cytokines surround these plaques producing a localized inflammatory environment in …
Fast And Sensitive Genome-Hashing Software And Its Application In Using Ngs As A Detection Agent For Bacterial Presence In Oral Metagenomic Samples, Paul Michael Gontarz
Fast And Sensitive Genome-Hashing Software And Its Application In Using Ngs As A Detection Agent For Bacterial Presence In Oral Metagenomic Samples, Paul Michael Gontarz
Dissertations
Next generation sequencing has increased the throughput of sequenced DNA into the range of billions of nucleotides sequenced per day. With the increased speed of DNA sequencing and the short length of reads produced by next generation sequencers, a significant challenge has been created in quickly and accurately assembling the hundreds of millions of short reads created by modern sequencing instruments into their full genomic sequences. With the increase in throughput in next generation sequencing and the decrease in time and cost to perform DNA sequencing, novel applications for DNA sequencing are being considered. Among them is a methodology by …