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Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of A Hybrid Baldwin Peptide: A Study In The Factors That Influence Helix Formation, Jay Steven Berger
Synthesis Of A Hybrid Baldwin Peptide: A Study In The Factors That Influence Helix Formation, Jay Steven Berger
Honors Theses
In this study, a hybrid i+4/i+3 peptide will be synthesized. It is assumed that this configuration will enhance the formation of the alphahelix. Previous research has determined that a complete helical tum requires 3.6 amino acid residues. The hybrid peptide will include four residues followed by a second helical tum which will only encompass three residues. It is hoped that by slightly over turning and then under turning the helix, the stability of the overall helix formation will be enhanced.
The Binding Of 2-Acetylnaphthalene To Beta-Cyclodextrin Polymers Studied By Fluorescence Quenching, Jason T. Graves
The Binding Of 2-Acetylnaphthalene To Beta-Cyclodextrin Polymers Studied By Fluorescence Quenching, Jason T. Graves
Honors Theses
Cyclodextrin (CD) molecules can form inclusion complexes with many different types of organics due to the hydrophobic environment of the CD internal cavity. The flurophore-2-acetylnapthalene (2-AN) has a high flourescence intensity in polar solvents such as water. Therefore, its fluorescence is quenched when it forms a complex with a CD molecule and is contained in the non-polar cavity. By measuring the change in flourescence intensity in the presence of CD, we can calculate the binding constant for CD:2-AN complex formation.
The Charge Of The Zinc Ion In Atcase And Its Effect On Tertiary Structure, Michelle L. Dietrich
The Charge Of The Zinc Ion In Atcase And Its Effect On Tertiary Structure, Michelle L. Dietrich
Honors Theses
Metals present in enzymes serve a variety of functions. Often they are involved in enzyme catalysis or regulation of enzymatic activity. Another interesting role metals play In enzymes is a structural one. A few enzymes depend on metals for their structural stability, such as the protein ATCase. The B chain of the protein contains a zinc ion that does not have a catalytic role and is predicted to stabilize the protein structure. The goal of this research is to model the area around the zinc In the B chain and to determine what effect the zinc has on the stability …
Nmr Studies Of Short Salt Bridged Peptides, James A. Ernst
Nmr Studies Of Short Salt Bridged Peptides, James A. Ernst
Honors Theses
The study of small helical peptides is an area of great interest in biochemistry. Baldwin has shown that salt bridging between residues with oppositely charged side chains can act to stabilize short helices. The order of increased helix stabilization shown by Baldwin was i+4AB>i+4BA>i+3AB>i+3BA where A is a positively charges amino acid side chain and B is a negatively charged amino acid side chain. Most previous studies have dealt with a single type of salt bridge stabilization, either i,i+3, or i,i+4 in a single peptide. This study will address the question of helix stabilization in a system …