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Design And Modeling Of Bioinspired Polyelectrolytes With Controlled Architectures For Gene Delivery Applications, Kelli Stockmal
Design And Modeling Of Bioinspired Polyelectrolytes With Controlled Architectures For Gene Delivery Applications, Kelli Stockmal
Dissertations
This dissertation focuses on the development of a range of bioinspired polyelectrolytes with controlled architectures for gene and drug delivery applications. Glycans are ubiquitous in biological systems, and understanding the role of saccharide stereochemistry, as well as cationic charge, on polymer behavior in aqueous solution and the interactions with nucleic acids can provide insight into how synthetic polyelectrolytes can be used for non-viral gene delivery and other biological applications. The first chapter provides an introductory overview on how cationic polyelectrolytes can be used to aid the delivery of RNA for controlling gene expression in a variety of cell types, how …
Investigation Of The Effects Of Hydrogen Bonding On The Enantiomeric Excess Of Pig Liver Esterase Hydrolysis Products, Matthew Hasler
Investigation Of The Effects Of Hydrogen Bonding On The Enantiomeric Excess Of Pig Liver Esterase Hydrolysis Products, Matthew Hasler
Honors Theses
Pig Liver Esterase (PLE) is an effective enzyme used in the Masterson Research Group due to its ability to hydrolyze only one ester in a malonic diester. PLE is employed for creating chiral molecules for the synthesis of unnatural amino acid precursors. Previous research in the group found that malonic half esters with hydrogen bonding capable substrates yielded varying degrees of enantiomeric excess, and non-hydrogen bonding substrates yielded racemic mixtures.1,2 The compounds synthesized contained substrates consisting of thiophene rings in the second and third position, and these molecules act as a control for the other research done in the group. …
Hydrogen Bond-Mediated Structural Order In Hydroxylated Bis-Mpa Dendritic Polymers: Experimental And Molecular Dynamics Simulation Study, Maliha N. Syed
Hydrogen Bond-Mediated Structural Order In Hydroxylated Bis-Mpa Dendritic Polymers: Experimental And Molecular Dynamics Simulation Study, Maliha N. Syed
Dissertations
Dendritic architectures are echoed throughout nature. While the significance of these pervasive patterns is not entirely clear, connections between their structures and physical properties are fascinating to contemplate. Particular interest has been paid to a family of synthetically manufactured and commercially available dendritic polymers based on 2,2-bis(hydroxymethyl) propionic acid (bis-MPA) as a monomer. Composed of two hydroxyls and a carboxyl group, bis-MPA based structures hydrogen bond (H-bond) profusely. Given the high concentration and unique spatial orientation of end-groups, as well as the multitude of carbonyl, ester, and ether interior H-bond acceptors, a set of distinct H-bond organizations may be observed …