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Full-Text Articles in Physical Sciences and Mathematics
Addressing The Issues Of Drug Delivery Via Advanced Macromolecular Design, Brooks Allen Abel
Addressing The Issues Of Drug Delivery Via Advanced Macromolecular Design, Brooks Allen Abel
Dissertations
The work described in this dissertation focuses on the development of synthetic approaches toward novel polymer architectures that specifically address the issues of in vivo drug delivery. Successful implementation of the synthetic methodologies described herein required fundamental investigations into the underlying chemistries in ways that now provide greater insights into the nature of the these chemical reactions.
In Section I, the synthesis of tunable pH- and CO2-responsive sulfonamide-containing polymers using reversible addition-fragmentation chain transfer (RAFT) polymerization is described. Initially, poor polymerization control of methacryloyl sulfonamide (MSA) monomers was observed using traditional RAFT polymerization conditions. Ultimately, reducing the polymerization …
Raft Synthesis Of Water-Soluble, Stimuli-Responsive Ab Diblock Copolymers, Ran Wang
Raft Synthesis Of Water-Soluble, Stimuli-Responsive Ab Diblock Copolymers, Ran Wang
Dissertations
A series of water-soluble, stimuli-responsive AB diblock copolymers were synthesized via the reversible addition-fragmentation chain transfer (RAFT) polymerization technique employing 2-(2- carboxyethylsulfanylthiocarbonylsulfanyl)propionic acid (CTA26) as the RAFT mediating agent.
First, a series of diacid functional trithiocarbonate chain transfer agents (CTA's) were synthesized and examined for their effectiveness as mediating agents in controlling the polymerization of «-butyl acrylate (nBA). Overall, CTA26 demonstrated good control in the homopolymerization of nBA with respect to the molecular weight and the molecular weight distribution, as well as its ability to form block copolymers with high reinitiating efficiency, and thus was chosen as the CTA for …