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Redox Studies On The Anti-Rheumatoid Arthritis Gold Drugs: Auranofin And Solganol, Ahmed A. Mohamed

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The oxidative behavior of Auranofin, 2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranosato-S(triethylphosphine)gold(I), was investigated by using cyclic voltammetry (CV) in 0.1 M Bu₄NBF₄/CH₂Cl₂ and 0.1 M Bu₄NPF₆/CH₂Cl₂ solutions using Pt working and auxiliary electrodes and a Ag/AgCl reference. CV studies at scan rates from 50-2,000mVs^-1 and Auranofin concentrations between 1 and 4mM, show two irreversible oxidation processes occurring at +1.1 V and +1.6 V vs. Ag/AgCl. Treatment of Auranofrn with the one electron oxidizing agent [Cp₂Fe]PF₆ gave a μ-thiolato digold cluster, [(Et₃PAu)₂(μ-SR)]₂^{2+ …}