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Articles 1 - 4 of 4
Full-Text Articles in Physical Sciences and Mathematics
Preparation Of G-Cuo Nps And G-Zno Nps With Mallow Leaves, Investigation Of Theirantibacterial Behavior And Synthesis Of Bis(Indolyl)Methane Compounds Under Solventfreemicrowave Assisted Dry Milling Conditions Using G-Cuo Nps As A Catalyst, Mi̇ne Sulak
Turkish Journal of Chemistry
In this study, biogenic copper and zinc oxide nanoparticles (G-ZnONPs and G-CuONPs) were synthesized by the green synthesis method using Malva parviflora L. (Millow) leaf extract and the obtained nanoparticles were characterized in detail with UVVis, FTIR, SEM, XRD. The antibacterial properties of the synthesized nanoparticles on gram-positive and gram-negative bacteria were investigated and it was found that the nanoparticles had high antimicrobial activity in the results of the experiments. With the obtained G-CuONPs, the synthesis of bis(indolyl)methanes with the "green" one-pot synthesis using microwave was achieved quickly and with high efficiency, and the thermal behavior of the obtained products …
Synthesis And Antimicrobial Investigation Of Some 5h-Pyridazino[4,5-B]Indoles, İlker Avan, Alaetti̇n Güven, Kiymet Güven
Synthesis And Antimicrobial Investigation Of Some 5h-Pyridazino[4,5-B]Indoles, İlker Avan, Alaetti̇n Güven, Kiymet Güven
Turkish Journal of Chemistry
Synthesis and in vitro antimicrobial activities are reported for a series of 1,3,5-substituted 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indole derivatives. Corresponding pyridazino[4,5-b]indoles were prepared from ethyl 3-formyl-1H-indole-2-carboxylate precursors and the functional group in question was installed with hydrazine and its derivatives. The purity and primary structures of pyridazino[4,5-b]indole were confirmed by IR, ^1 H NMR, and ^{13}C NMR spectroscopy and elemental analyses. All of the indoles were tested for in vitro antimicrobial activity against 8 isolates of bacteria and a fungus including Staphylococcus aureus NRRL B-767, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Proteus vulgaris NRRL-B123, Salmonella typhimurium NRRL B-4420, Bacillus subtilis NRRL 744, …
Synthesis And Antioxidant And Antimicrobial Evaluation Of Novel 4-Substituted-1h-1,2,4-Triazole Derivatives, Sultan Baytaş, Evi̇n Kapçak, Tülay Çoban, Hati̇ce Özbi̇lge
Synthesis And Antioxidant And Antimicrobial Evaluation Of Novel 4-Substituted-1h-1,2,4-Triazole Derivatives, Sultan Baytaş, Evi̇n Kapçak, Tülay Çoban, Hati̇ce Özbi̇lge
Turkish Journal of Chemistry
A series of 4-benzyl/phenyl-3-(1-methyl-1H-indole-2-yl)-1H- 1,2,4-triazole-5(4H)-thione (4a,b) and 2-{4-[benzyl/phenyl-5- (substitutedbenzylthio)]-4H-1,2,4-triazole-3-yl}-1-methyl-1H-indole derivatives (5a-p) were synthesized and evaluated for their in vitro scavenging of DPPH and superoxide radical, and lipid peroxidation inhibition effects as well as their antimicrobial properties. DPPH radical scavenging capacity was found to be equipotent with BHT and found in compounds containing 1,2,4-triazole-5(4H)-thione moiety (4a,b). With regard to antimicrobial properties, compound 5k showed slight antimicrobial activity against all the test microorganisms.
Design, Synthesis, And Biological Evaluation Of Indole-Based 1,4-Disubstituted Piperazines As Cytotoxic Agents, Meri̇ç Köksal Akkoç, Mi̇ne Yarim Yüksel, İrem Durmaz, Rengül Çeti̇n Atalay
Design, Synthesis, And Biological Evaluation Of Indole-Based 1,4-Disubstituted Piperazines As Cytotoxic Agents, Meri̇ç Köksal Akkoç, Mi̇ne Yarim Yüksel, İrem Durmaz, Rengül Çeti̇n Atalay
Turkish Journal of Chemistry
A series of 3-[(4-substitutedpiperazin-1-yl)methyl]-1H-indole derivatives were synthesized, and their structures were confirmed by spectral analysis. All the compounds were tested for their cytotoxic activity in vitro against 3 human tumor cell lines: human liver (HUH7), breast (MCF7), and colon (HCT116). Among the designed derivatives, most of the compounds showed significant cytotoxicity against liver and colon cancer cell lines with lower IC_{50} concentrations than the standard drug 5-fluorouracil. Compound 3s, with 3,4-dichlorophenyl substituent on the piperazine ring, was the most active in suppressing the growth of all screened cancer cells.