Physical Sciences and Mathematics Commons^™

Structure-Activity Relationship Of Anticancer Drug Candidate Quinones, Nadire Özenver, Neslihan Sönmez, Merve Yüzbaşıoğlu Baran, Ayşe Uz, Lütfiye Ömür Demi̇rezer

Turkish Journal of Chemistry

Breast cancer is one of the most prevalent cancer types worldwide. Chemotherapy is a substantial approach in the management of breast cancer despite the occurrence of chemotherapy-associated side effects and the development of multidrug resistance in cancer cells. At this point, a variety of quinone derivatives may represent potential as possible anticancer drug candidates due to possessing structural similarity towards clinically used anticancer drugs like doxorubicin. Therefore, we investigated the cytotoxic effects of various quinone derivatives with structural diversity towards a variety of breast cancer cells. We further determined their toxicity in healthy cells to evaluate their drug capability potential. …