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Exploration Of Novel 6,8,9-Trisubstituted Purine Analogues: Synthesis, In Vitro Biological Evaluation, And Their Effect On Human Cancer Cells, Muhammed Fatih Polat, İrem Durmaz Şahi̇n, Rengül Atalay, Meral Tunçbi̇lek

Turkish Journal of Chemistry

Cancer, a leading global cause of mortality, demands continuous advancements in therapeutic strategies. This study focuses on the design and synthesis of a novel series of purine derivatives, specifically 6-(substituted phenyl piperazine)-8-(4-phenoxyphenyl)-9-cyclopentyl purine derivatives (5–11). The motivation behind this endeavor lies in addressing acquired resistance mechanisms in cancer cells, a significant hurdle in current treatment modalities. The synthesis, starting from 4,6-dichloro-5-nitropyrimidine, involves a multi-step process, resulting in seven new purine derivatives. Biological evaluation against human liver, colon, and breast cancer cells (Huh7, HCT116, and MCF7, respectively) was performed using the SRB assay. Among the synthesized analogs, compounds 5 and 6, …